Synthesis, Characterisation And Cytotoxic Activity Of Random Copolyester Using 1,4- Dithiane- 2,5-diol
B. Kalpana1,*, R. Nanthini2
Volume 5, Issue 1, Page 20010393 (1-4), Year 2020 | DOI: 10.5185/amp.2020.010393
Keywords: Copolyester, 1,4-dithiane-2,5-diol, anticancer, antioxidant
Abstract: A novel random copolyester Poly(1,4-dithiane-2,5-diol Succinate – Co – 1,2-ethane diol Succinate) PDES containing sulphur atom was synthesised by direct melt polycondensation method using 1,4- dithiane-2,5-diol as a special monomer, succinic acid, and 1,3 ethane diol with Titanium tetra isopropoxide as catalyst. The wide range of application of the special monomer especially as biocontrol material and food additive led us to extend our area of research towards producing copolyester with cytotoxic activity. The various physical properties of the copolyester such as inherent viscosity, glass transition temperature, solubility and crystalline nature was investigated and studied in detail. The 1H-NMR and FT-IR was done to investigate the chemical properties of the PDES copolyester. In Vitro cytotoxicity against Normal (Vero cell line) and cancer (A549 Lung cancer cell line) by MTT Assay, Antioxidant activity by Dot-Blot/DPPH scavenging Assay and Antimicrobial by Well diffusion method studies proved that the synthesised copolyester have immense biological properties and could be used in biomedical application.