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Research Article Open Access

The Fabrication of Green and Sustainable Pathway for the Synthesis of Bis-indolyl Methane Scaffolds

Devendra S. Raghuvanshi1, Jyotsna S. Meshram2*

1R&D, Shiva Pharmachem Pvt. Ltd., Luna, Tal – Padra, Dist. Vadodara 391 440, Gujarat, India

2Department of Chemistry, Rashtra Sant Tukdoji Maharaj Nagpur University, Nagpur 440 010, Maharashtra, India

Adv. Mater. Proc., 2020, 5 (4), 20040415

DOI: 10.5185/amp.2020.040415

Publication Date (Web):10/08/2020

Copyright © IAAM-VBRI Press

Abstract


The green and efficient procedure for the preparation of substituted bis-indolyl methane via condensation of indole with various aryl aldehydes (3 MCR) in the presence of catalytic amount MFA (Modified Fly Ash; a zeotype catalyst) at reflux temperature in good to excellent yield (85-95%) is reported. This method is utilizing the solvent free condition with the beneficial features such as short reaction time and easy process for isolation. The rate of reactions is found to relay on EDGs and EWGs substituents present on aryl aldehydes at particular positions.

 

Keywords


MFA, EDGs, EWGs, Bis-indolyl methane, MCR.