Research Article Open Access
Design, Synthesis and Bio-evaluation of New Phenothiazine Derivatives of Sulfonamide Dyes as Anticancer Agents
Manoj D. Shanti1,*, Kaveri D. Shanti2,*, Jyotsna Meshram2, Manisha Raut3, Kamlakar Nandekar1
1G.H. Raisoni College of Engineering, Nagpur, Maharashtra 440016, India
2Department of Chemistry, RTM Nagpur University, Nagpur, Maharashtra 440033, India
3Rajiv Gandhi College of Engineering & Research, Nagpur, Maharashtra 441110, India
Adv. Mater. Proc., 2020, 5 (3), 20030406
Publication Date (Web):04/07/2020
Copyright © IAAM-VBRI Press
A series of new phenothiazine derivatives of sulfonamide dyes was designed, synthesized & evaluated for their potent anti-cancer activities. The compounds were designed on the basis of molecular docking studies. Firstly they were docked with three different anticancer target enzymes viz. topoisomerase-II, aromatase and CDK2 and on the basis of dock score the designed compounds were synthesized.
All synthesized compounds were bio-evaluated for their in-vitro anti-cancer action which displayed adequate results in agreement with the outcome of docking study.