Research Article Open Access
Design, Synthesis and Bio-evaluation of New Phenothiazine Derivatives of Sulfonamide Dyes as Anticancer Agents
Manoj D. Shanti, Kaveri D. Shanti, Jyotsna Meshram, Manisha Raut, Kamlakar Nandekar
1G.H. Raisoni College of Engineering, Nagpur, Maharashtra 440016, India
2Department of Chemistry, RTM Nagpur University, Nagpur, Maharashtra 440033, India
3Rajiv Gandhi College of Engineering & Research, Nagpur, Maharashtra 441110, India
Adv. Mater. Proc., 2020, 5 (3), 20030406
DOI: 10.5185/amp.2020.030406
Publication Date (Web):04/07/2020
Copyright © IAAM-VBRI Press
A series of new phenothiazine derivatives of sulfonamide dyes was designed, synthesized & evaluated for their potent anti-cancer activities. The compounds were designed on the basis of molecular docking studies. Firstly they were docked with three different anticancer target enzymes viz. topoisomerase-II, aromatase and CDK2 and on the basis of dock score the designed compounds were synthesized. All synthesized compounds were bio-evaluated for their in-vitro anti-cancer action which displayed adequate results in agreement with the outcome of docking study.