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Research Article Open Access

Design, Synthesis and Bio-evaluation of New Phenothiazine Derivatives of Sulfonamide Dyes as Anticancer Agents

 

Manoj D. Shanti1,*, Kaveri D. Shanti2,*, Jyotsna Meshram2, Manisha Raut3, Kamlakar Nandekar1

 

1G.H. Raisoni College of Engineering, Nagpur, Maharashtra 440016, India

2Department of Chemistry, RTM Nagpur University, Nagpur, Maharashtra 440033, India

3Rajiv Gandhi College of Engineering & Research, Nagpur, Maharashtra 441110, India

 

Adv. Mater. Proc., 2020, 5 (3), 20030406

DOI: 10.5185/amp.2020.030406

Publication Date (Web):04/07/2020

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Abstract

A series of new phenothiazine derivatives of sulfonamide dyes was designed, synthesized & evaluated for their potent anti-cancer activities. The compounds were designed on the basis of molecular docking studies. Firstly they were docked with three different anticancer target enzymes viz. topoisomerase-II, aromatase and CDK2 and on the basis of dock score the designed compounds were synthesized. All synthesized compounds were bio-evaluated for their in-vitro anti-cancer action which displayed adequate results in agreement with the outcome of docking study.

Keywords

Docking, topoisomerase-II, aromatase enzyme, CDK2, phenothiazine derivatives of sulfonamide, anticancer evaluation

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