Research Article Open Access

Design, Synthesis and Bio-evaluation of New Phenothiazine Derivatives of Sulfonamide Dyes as Anticancer Agents

**Manoj D. Shanti^1,, Kaveri D. Shanti^2,, Jyotsna Meshram², Manisha Raut³, Kamlakar Nandekar¹**

¹G.H. Raisoni College of Engineering, Nagpur, Maharashtra 440016, India

²Department of Chemistry, RTM Nagpur University, Nagpur, Maharashtra 440033, India

³Rajiv Gandhi College of Engineering & Research, Nagpur, Maharashtra 441110, India

Adv. Mater. Proc., 2020, 5 (3), 20030406

DOI: 10.5185/amp.2020.030406

Publication Date (Web):04/07/2020

Abstract

A series of new phenothiazine derivatives of sulfonamide dyes was designed, synthesized & evaluated for their potent anti-cancer activities. The compounds were designed on the basis of molecular docking studies. Firstly they were docked with three different anticancer target enzymes viz. topoisomerase-II, aromatase and CDK2 and on the basis of dock score the designed compounds were synthesized.
All synthesized compounds were bio-evaluated for their in-vitro anti-cancer action which displayed adequate results in agreement with the outcome of docking study.

Keywords

Docking, topoisomerase-II, aromatase enzyme, CDK2, phenothiazine derivatives of sulfonamide, anticancer evaluation

Design, Synthesis and Bio-evaluation of New Phenothiazine Derivatives of Sulfonamide Dyes as Anticancer Agents

**Manoj D. Shanti^1,, Kaveri D. Shanti^2,, Jyotsna Meshram², Manisha Raut³, Kamlakar Nandekar¹**

Abstract

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Design, Synthesis and Bio-evaluation of New Phenothiazine Derivatives of Sulfonamide Dyes as Anticancer Agents

Manoj D. Shanti1,*, Kaveri D. Shanti2,*, Jyotsna Meshram2, Manisha Raut3, Kamlakar Nandekar1

Abstract

Keywords

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**Manoj D. Shanti^1,, Kaveri D. Shanti^2,, Jyotsna Meshram², Manisha Raut³, Kamlakar Nandekar¹**