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Research Article Open Access

Anticancer property of green material through computational approach

Nupur Jauhari1, Gajula MNV Prasad2, Neelam Sharma3, Navneeta Bharadvaja1*

1Department of Biotechnology, Delhi Technological University, Bawana Road, Delhi 110042 India

2Institute of Biotechnology, PJTSAU, Rajendra Nagar, Hyderabad 500030, India

3ICAR-National Bureau of Plant Genetic Resources, Pusa Campus, New Delhi 110 012, India

Adv. Mater. Proc., 2017, 2 (6), 378-383

DOI: 10.5185/amp.2017/606

Publication Date (Web):05 June 2017

Copyright © IAAM-VBRI Press

Abstract


Abstracts

The purpose of research: Colorectal cancer is third most prevalent cancer in developed countries with increasing cases in developing countries. Studies show that the chronic intestinal inflammation is associated with increased risk of developing colorectal cancer. Inflammation is an immunological response to external damaging stimuli and is govern by an endogenous pyrogen and pleiotropic pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α).  TNF-α plays an important role in the development of humoral immune response. Production of TNF-α has been implicated in various other pathologies including diabetes, osteoporosis, multiple sclerosis and inflammatory bowel diseases also. Several studies have shown that anti-inflammatory effect of stigmasterol, a phytosterol of an endangered medicinal plant Chlorophytum borivilianum, is mediated by suppression of TNF-α. The latter is synthesized as a membrane-anchored precursor. The soluble form of TNF-α is released into extracellular space by tumor necrosis factor alpha converting enzyme (TACE), a multidomain metalloproteinase.

Keywords


Colon cancer, molecular docking, stigmasterol, TACE, TNF-α.