In Vitro Antibacterial And Anticancer Studies Of ZnO Nanoparticles Prepared By Sugar Fueled Combustion Synthesis

Prashanth Gopala Krishna1, 2, Prashanth Paduvarahalli Ananthaswamy3*, Manoj Gadewar4, Utpal Bora4, Nagabhushana Bhangi Mutta5

1Department of Chemistry, Sir M. Visvesvaraya Institute of Technology, Bengaluru 562157, India

2Research and Development Center, Bharathiar University, Coimbatore 641046, India

3Department of Chemistry, Sai Vidya Institute of Technology, Bengaluru 560 064, India

4Department of Bioscience and Bioengineering, Indian Institute of Technology, Guwahati 781039, India

5Department of Chemistry, M. S. Ramaiah Institute of Technology, Bengaluru 560054, India

Adv. Mater. Lett., 2017, 8 (1), pp 24-29

DOI: 10.5185/amlett.2017.6424

Publication Date (Web): Nov 12, 2016

E-mail: prsnthmysore@gmail.com

Abstract


In this study, we report the antibacterial and anticancer activity of ZnO nanoparticles (NPs) prepared by sugar-fueled solution combustion synthesis. The structure and morphology of the sample were determined by XRD, UV-visible, FESEM and HRTEM. Surface area measurement was carried out by standard Brunauer-Emmett-Teller technique. Antibacterial activity of ZnO NPs was tested against Clostridium perfringens and Salmonella enterica by well diffusion method. The anticancer efficacy of ZnO nanoparticles was carried out on breast cancer cells MCF-7. The antibacterial results affirm that spherical ZnO NPs constitute as a successful bactericidal agent against both Gram-positive and Gram-negative bacteria. Anticancer result indicates that ZnO NPs exert dose dependent toxicity in MCF-7.

Keywords

Combustion synthesis, clostridium perfringens, salmonella enterica, MCF-7, MTT assay.

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