Alumina Nanoparticles: A New And Reusable Catalyst For Synthesis Of Dihydropyrimidinones Derivatives

¹P.G. Department of Chemistry, Seth Kesarimal Porwal College, Kamptee, RTM Nagpur University, Kamptee 441001, India

²P. G. T. Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University Nagpur 440033, India

³Department of Chemistry, Nabira Mahavidyalaya, Katol, RTM Nagpur University, Katol 441302, India  

Adv. Mater. Lett., 2016, 7 (11), pp 933-938

DOI: 10.5185/amlett.2016.6245

Publication Date (Web): Oct 01, 2016

Copyright © IAAM-VBRI Press

E-mail:chaudhary_rati@yahoo.com, ratswat81@yahoo.com

Abstract

Present study demonstrates the synthesis of alumina nanoparticles (NPs) by sol-gel method and characterized by various standard microscopic techniques like Powder X-ray Diffraction (PXRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Atomic Force Microscopy (AFM), Energy Dispersive Spectroscopy (EDS), FT-IR, UV-visible, and Thermogravimetry-Differential Thermogravimetry (TG-DTA) to evaluate the size, shape and composition of nanoparticles. Furthermore, a solvent free green synthesis of 3, 4-dihydropyrimidinones derivatives were carried by using alumina nanoparticles (γ-Al₂O₃ NPs) as a catalyst through Biginelli reaction of aromatic aldehydes, β-ketoesters, and urea. The structures of the obtained products were confirmed by Fourier transform infrared (FT-IR), and proton nuclear magnetic resonance (¹H NMR) spectra. Effective results were obtained by using nano catalyst. Therefore, present protocol is favored as it offers advantages of higher productivity, short reaction times, simplicity and easy workup. Besides, catalyst is an inexpensive, reusable and recyclable up to four cycles without loss of its activity.

Keywords

Alumina NPs, microscopic techniques, reusable catalyst, dihydropyrimidinones derivatives, biginelli reaction.