Eco-friendly Approach: Graphene Like Boron Nitride Modified Calcium Material For The Synthesis Of 2-amino-4H-pyran-3-carbonitrile Derivatives

T. Muthu, K. Anand, M. Sureshkumar, R. M. Gengan*

Department of Chemistry, Faculty of Applied Sciences, Durban University of Technology, Durban 4001, South Africa

Adv. Mater. Lett., 2016, 7 (10), pp 790-794

DOI: 10.5185/amlett.2016.6850

Publication Date (Web): Aug 01, 2016

E-mail:genganrm@dut.ac.za

Abstract


An efficient one-pot multi-component synthesis of medicinally important 2-amino-4H-pyran-3-carbonitrile derivatives using a new heterogeneous calcium loaded boron nitride (CaBNT) catalyst is described herein. This transformation transpires by Knoevenagel condensation, Michael addition and intramolecular cyclization. Alkaline earth metal-based green catalyst was successfully prepared and characterized by XRD, SEM with EDX, Raman spectroscopy, BET, DSC-TGA and FT-IR. The reaction works up is facile and CaBNT catalyst can easily be separated from the reaction mixture and re-used more than five times in subsequent reactions. This methodology offers several advantages such as excellent yields, use of inexpensive solvent and relatively shorter reaction time.

Keywords

Heterogeneous catalyst, calcium, boron nitride, multi-component synthesis.

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