Comparative Evaluation Of Ion Exchange Resins And Fibers In Iontophoretic Transdermal Delivery Of Sumatriptan Succinate

Pallavi D. Vispute1, Milind P. Wagh1*, Nazma N. Inamdar2

1Department of Pharmaceutics, M.V.P. Samaj’s College of Pharmacy, Savitribai Phule Pune University, Gangapur Road, Nashik 422002,India

2Department of Pharmaceutical Chemistry, Allana College of Pharmacy, Savitribai Phule Pune University, Pune 411001, India

Adv. Mater. Lett., 2016, 7 (9), pp 754-759

DOI: 10.5185/amlett.2016.6158

Publication Date (Web): Jul 09, 2016

E-mail: drmilindwagh@gmail.com

Abstract


Iontophoresis is a convenient and suitable technique for delivering charged sumatriptan succinate (SS) across the skin. The objective of study was to examine the applicability of ion exchange resins and fibers as drug carrier to enhance the efficiency of transdermal iontophoresis. The complexes of drug with cationic resins Indion 204 and Indion 224 (DRC-1, DRC-2) as well as with fibers Smopex 102 and Smopex 101 (DFC-1, DFC-2) were formed by batch method. These complexes were characterized by DSC and PXRD and compared for drug loading, drug release and permeation across rat skin. Effects of constant and pulsed current iontophoresis on drug permeation were also evaluated. The iontophoresis study was conducted using silver–silver chloride electrodes across rat skin. The results suggested that fibers due to their open structure showed more drug loading and release compared to resins. The transdermal flux as well as amount of drug permeated from drug-fiber complexes was higher as compared to that of drug-resin complexes and drug solution. DFC-2 assisted with pulsed iontophoresis at 50 % duty cycle significantly increased the skin permeation of SS and reduced the fluctuation in drug permeation with constant drug delivery compared with the passive controls.

Keywords

Iontophoresis, ion exchange resins, ion exchange fibers, sumatriptan succinate, transdermal drug delivery.

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