Cover Page September-2016-Advanced Materials Letters

Advanced Materials Letters

Volume 7, Issue 9, Pages 754-759, September 2016
About Cover


Comparative Evaluation Of Ion Exchange Resins And Fibers In Iontophoretic Transdermal Delivery Of Sumatriptan Succinate

Pallavi D. Vispute1, Milind P. Wagh1*, Nazma N. Inamdar2

1Department of Pharmaceutics, M.V.P. Samaj’s College of Pharmacy, Savitribai Phule Pune University, Gangapur Road, Nashik 422002,India

2Department of Pharmaceutical Chemistry, Allana College of Pharmacy, Savitribai Phule Pune University, Pune 411001, India

Adv. Mater. Lett., 2016, 7 (9), pp 754-759

DOI: 10.5185/amlett.2016.6158

Publication Date (Web): Jul 09, 2016

E-mail: drmilindwagh@gmail.com

Abstract

Iontophoresis is a convenient and suitable technique for delivering charged sumatriptan succinate (SS) across the skin. The objective of study was to examine the applicability of ion exchange resins and fibers as drug carrier to enhance the efficiency of transdermal iontophoresis. The complexes of drug with cationic resins Indion 204 and Indion 224 (DRC-1, DRC-2) as well as with fibers Smopex 102 and Smopex 101 (DFC-1, DFC-2) were formed by batch method. These complexes were characterized by DSC and PXRD and compared for drug loading, drug release and permeation across rat skin. Effects of constant and pulsed current iontophoresis on drug permeation were also evaluated. The iontophoresis study was conducted using silver–silver chloride electrodes across rat skin. The results suggested that fibers due to their open structure showed more drug loading and release compared to resins. The transdermal flux as well as amount of drug permeated from drug-fiber complexes was higher as compared to that of drug-resin complexes and drug solution. DFC-2 assisted with pulsed iontophoresis at 50 % duty cycle significantly increased the skin permeation of SS and reduced the fluctuation in drug permeation with constant drug delivery compared with the passive controls.

Keywords

Iontophoresis, ion exchange resins, ion exchange fibers, sumatriptan succinate, transdermal drug delivery.

Previous issues

Cloud Medicine set to Revolutionize Doorstep Personalized Healthcare

Various surfactants for 0 – 3 dimensional nanocarbons: Separation, exfoliation and solubilization

Polypyrrole based biofunctional composite layer for bioelectrocatalytic device system

Innovative Graphene-PDMS sensors for aerospace applications 

Effect of hot drawing process and carbonization temperature in electrochemical behavior of electrospun carbon nanofibers

Chemical Reactivity and Electronical Properties of Graphene and Reduced Graphene Oxide on Different Substrates

Laser Raman micro-spectroscopy as an effective non-destructive method of detection and identification of various sp2 carbon modifications in industry and in nature

Electrochemical promotion of ammonia synthesis with proton-conducting solid oxide fuel cells

Biomimetic surfaces with hierarchical structure using microsized texture and nanosized Cu particles for superhydrophobicity

Enhancement the properties of high and low-density polyethylene membranes by radiation grafting process

Synthesis of 9-Aminoacridine and its Application as an Anode Material for Aqueous Rechargeable Lithium–ion Batteries

Facile synthesis of novel tough and highly flexible biodegradable membranes for water microfiltration

Investigating the possibility of using acetic acid in place of HF in chromium-benzenedicarboxylates (MIL-53 and MIL-101) synthesis applicable for CO2 adsorption

Upcoming Congress

Knowledge Experience at Sea TM