Preparation And Characterization Of Polyvinyl Alcohol–pectin Cryogels Containing Enrofloxacin And Keratinase As Potential Transdermal Delivery Device

Jimena S. Gonzalez1*, Yanina N. Martínez2, Guillermo R.Castro2, Vera A. Alvarez1

1Grupo de Materiales Compuestos de Matriz Polimérica (CoMP)- Instituto de investigación en Ciencia y Tecnología de Materiales - INTEMA (CONICET-UNMdP), Solis 7575, (B7608FDQ) Mar del Plata (B7608FDQ), Argentina

2Laboratorio de Nanobiomateriales, CINDEFI - Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata - CONICET (CCT La Plata), 1900, La Plata, Argentina

 

Adv. Mater. Lett., 2016, 7 (8), pp 640-645

DOI: 10.5185/amlett.2016.6499

Publication Date (Web): Jul 01, 2016

E-mail: jimena.gonzalez@fi.mdp.edu.ar

Abstract


Polyvinyl alcohol (PVA) and polyvinyl alcohol-pectin (PVA-P) cryogels are potential devices for wound healing. These materials have advantages over commercial wound dressings such as: retaining an appropriate level of moisture around wound and gas permeability and antibacterial properties. In a previous work, PVA-P cryogels containingan antibiotic and an enzyme (enrofloxacin and keratinase respectively) have been developed with promising results. In the present work, an exhaustive chemical, morphological and physical characterization of these films was carried out in order to explain the effect of incorporation of pectin into PVA matrix. The results show that the presence of pectin in PVA cryogel increase the size of PVA nanodomains determined by XRD patterns indicating an interaction between both PVA and pectin polymers. PVA nanodomains and crystallinity degree changed when enrofloxacin and keratinase were immobilized into PVA-P cryogels determined by SAXS and DSC analysis. These results suggest a good incorporation of both drugs into the polymeric matrix. A model involving the complex formation between the enzyme and enrofloxacin allocated through and between PVA nanodomains is proposed and it correlates well with results obtained in previous work where enrofloxacin kinetic release was found retarded by the presence of keratinase in the cryogels.

Keywords

PVA, pectin, enrofloxacin, keratinase, cryogel.

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