1Grupo de Materiales Compuestos de Matriz Polimérica (CoMP)- Instituto de investigación en Ciencia y Tecnología de Materiales - INTEMA (CONICET-UNMdP), Solis 7575, (B7608FDQ) Mar del Plata (B7608FDQ), Argentina
2Laboratorio de Nanobiomateriales, CINDEFI - Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata - CONICET (CCT La Plata), 1900, La Plata, Argentina
Adv. Mater. Lett., 2016, 7 (8), pp 640-645
DOI: 10.5185/amlett.2016.6499
Publication Date (Web): Jul 01, 2016
Copyright © IAAM-VBRI Press
E-mail: jimena.gonzalez@fi.mdp.edu.ar
Polyvinyl alcohol (PVA) and polyvinyl alcohol-pectin (PVA-P) cryogels are potential devices for wound healing. These materials have advantages over commercial wound dressings such as: retaining an appropriate level of moisture around wound and gas permeability and antibacterial properties. In a previous work, PVA-P cryogels containingan antibiotic and an enzyme (enrofloxacin and keratinase respectively) have been developed with promising results. In the present work, an exhaustive chemical, morphological and physical characterization of these films was carried out in order to explain the effect of incorporation of pectin into PVA matrix. The results show that the presence of pectin in PVA cryogel increase the size of PVA nanodomains determined by XRD patterns indicating an interaction between both PVA and pectin polymers. PVA nanodomains and crystallinity degree changed when enrofloxacin and keratinase were immobilized into PVA-P cryogels determined by SAXS and DSC analysis. These results suggest a good incorporation of both drugs into the polymeric matrix. A model involving the complex formation between the enzyme and enrofloxacin allocated through and between PVA nanodomains is proposed and it correlates well with results obtained in previous work where enrofloxacin kinetic release was found retarded by the presence of keratinase in the cryogels.
Advancing Materials towards Climate Neutrality by 2050
Efficiency of Nanomaterials for Electrochemical Diagnostics based Point-of-Care Detection of Non-Invasive Oral Cancer Biomarkers
Hybrid Membrane based on Polymer-doped Phosposilicate and their Characterization
A DFT Study of Interaction of (CdSe)3 Quantum Dots with Nucleobases
Low Resistance and High Electromigration Lifetime of Cu-To-Cu Joints Using (111)-Oriented Nanotwinned Copper
Electrochemical Hydrogen Evolution Reaction Triggered by Co2xMo1-xS2 (x = 0. 0.05 and 0.1) in Acidic Medium
Effect of La Dopant in Modified Bismuth Ferrite Ceramics
Biogenic Capped Silver Nanoparticles in Lablal Purpureus Pod Extract Exhibit Selective Antibacterial and Synergistic Anticancer Activity
Transforming Paradigm of Artificial Intelligence for Scalable Clinical Healthcare
A Review on Harnessing Nanomaterials as Promising Materials Interface
A New Epidemic Spreading Model to Predict the Spread and Accumulation of Corona Virus (COVID-19) Positive Cases as a Function of Time
Green Synthesis of ZnO and Ag-ZnO Nanoparticles using Macrotyloma Uniflorum: Evaluation of Antibacterial Activity
Feature Behavior of Resistivity in Bi Foils Obtained by a Melt Spinning Method
Thermomagnetic Properties of Metal and Metal-oxide Nanoparticles
Effect on Structural, Electrical and Temperature Sensing behavior of Neodymium Doped Bismuth Ferrite
Novel Green Chemistry Synthesis of Nano-Hydroxyapatite using Soya Milk as a Natural Stabiliser
Copyright ©2010-2021 VBRI Press
Full Article