Cover Page March-2015-Advanced Materials Letters

Advanced Materials Letters

Volume 6, Issue 3, Pages 187-193, March 2015
About Cover


In Vivo Genotoxic Assessment Of Silver Nanoparticles In Liver Cells Of Swiss Albino Mice Using Comet Assay

Kumud Kant Awasthi1*, Rajbala Verma1, Anjali Awasthi1, Kamlendra Awasthi2, Inderpal Soni1, P.J. John1*

1Department of Zoology, University of Rajasthan, Jaipur 302004, India

2Department of Physics, Malaviya National Institute of Technology, Jaipur 302017, India

Adv. Mater. Lett., 2015, 6 (3), pp 187-193

DOI: 10.5185/amlett.2015.5640

Publication Date (Web): Feb 22, 2015

E-mail: kkantawasthi@gmail.com, plachenljohn@yahoo.com

Abstract

Silver nanoparticles (Ag NPs) has resulted their incorporation into consumer products due to their extensive application in health, electronic, and household products. In particular, the oral toxicity of Ag NPs is of particular concern to ensure public health. For the present study, a genotoxic and cytotoxic approach was employed to elucidate the activity of 5 nm size and spherical shaped Ag NPs in liver cells of Swiss albino mice by using alkaline comet assay. Statistically significant DNA damage raise the concern about the safety associated with the applications of the Ag NPs. The result showed that Ag NPs induced a significant concentration dependent increase in the frequency of tailed nuclei (DNA damage), tail moment, %DNA in the tail, and tail length in the liver cells. Additionally significant histopathological alterations were also observed. The results of present study suggest that exposure to silver nanoparticles has the potential to cause genetic damage.

Keywords

Silver nanoparticles, DNA damage, liver function, comet assay, histopathology.

Previous issues

Current Global Scenario of Electric Vehicles

Review on Detection of Phenol in Water 

Investigating the Machinability of Metallic Matrix Composites Reinforced by Carbon Nanotubes: A Review

Photocatalytic ZnO based PES Membranes for AOP Water Treatments under UV and Sunlight

Plasma Activated Water as a Source of Nitrogen for Algae Growth

Digital Light Processing (DLP) 3D Printing of Polyethylene Glycol (PEG) Biopolymer, Commercially available Ultra-High and Tough (UHT) Resin and Maghemite (γ-Fe2O3) Nanoparticles Mixture for Tissue Engineering Scaffold Application

Fabrication of Nanoparticle Embedded Polymeric Microbeads as an Efficient Drug Delivery System

Micro/Nanostructured Papers from Bagasse Pulp Reinforced by Nanofibrillated Cellulose from different Agro-Waste Sources

Structural, Optical and Magnetic Properties of Pristine, (Mn, Al) co-doped ZnO Nanocrystallites Synthesized via co-Precipitation Method

Nanosecond Laser Surface Patterning of Ti6Al4V Bio-alloy for Improved Biological Performance

Synthesis of Cu2O/Ag Composite Nanocubes with Promising Photoluminescence and Photodegradation Activity over Methylene Blue Dye

Locally available Clays of Bangladesh as a Replacement of imported Clays for Ceramic Industries 

Green Synthesis and Characterization of Silver Nanoparticles using Cassia auriculata Leaves Extract and Its Efficacy as A Potential Antibacterial and Cytotoxic Effect

Upcoming Congress

Knowledge Experience at Sea TM