Pomosynthesis And Biological Activity Of Silver Nanoparticles Using Passiflora Tripartita Fruit Extracts

Brajesh Kumar1*, Kumari Smita1, Luis Cumbal1*, Alexis Debut1, Javier Camacho1,2, Elisabeth Hernández-Gallegos2, María de Guadalupe Chávez-López2, Marcelo Grijalva1, Yolanda Angulo1, Gustavo Rosero

1Centro de Nanociencia y Nanotecnologia, Universidad de las Fuerzas Armadas -ESPE, Av. Gral. Rumiñahui s/n, Sangolqui, P.O. BOX 171-5-231B, Ecuador

2Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Departamento de Farmacología. C.P. 07360, Mexico City, Mexico

Adv. Mater. Lett., 2015, 6 (2), pp 127-132

DOI: 10.5185/amlett.2015.5697

Publication Date (Web): Feb 08, 2015

E-mail: krmbraj@gmail.com, lhcumbal@espe.edu.ec

Abstract


Silver nanoparticles (AgNPs) have been synthesized via the green pomosynthetic procedure, using Passiflora tripartita var. mollissima fruit pigments as both the reducing and stabilizing agents. UV–Vis Spectroscopy, Dynamic Light Scattering, Transmission Electron Microscopy with Selected Area Electron Diffraction and Powder X-Ray Diffraction are used to completely characterize the AgNPs. The prepared AgNPs are found to be mostly spherical shapes with an average diameter of 49.7 ± 24.6 nm at room temperature. XRD analysis revealed the face-centered cubic geometry of AgNPs whereas Infrared spectrum and cyclic voltammetry measurements hypothesize the possible biomolecules (flavonoid C & O-glycosides) responsible for stabilization of the AgNPs. Synthesized AgNPs shows significant antioxidant efficacy (67%, 0.15 mM) against 1, 1-diphenyl-2- picrylhydrazyl. The AgNPs (0.01 – 20 μΜ) did not affect cell proliferation of the human cancer cell lines A -549 and HeLa, from lung and cervix, respectively. The use of environmentally benign, cost-effective and renewable materials like P. tripartita extract offers numerous benefits of eco-friendliness and compatibility for potential future pharmaceutical and biomedical applications.

Keywords

Silver nanoparticles, Passiflora tripartita, TEM, XRD, antioxidant, cancer cells.

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