Anti-emetic Drug Delivery For Cancer Patients Through Electrospun Composite Nanofibers Transdermal Patch: In Vitro Study

Damanpreet Kaur1, Ashish Gupta1, Nahar Singh2 and Sanjay R. Dhakate1* 

1Physics and Engineering of Carbon, Division of Material Physics and Engineering, CSIR-National Physical Laboratory

2Analytical Chemistry Section, CSIR-National Physical Laboratory, Dr. K. S. Krishnan Marg, New Delhi 110012, India

Adv. Mater. Lett., 2015, 6 (1), pp 33-39

DOI: 10.5185/amlett.2015.5594

Publication Date (Web): Dec 28, 2014

E-mail: dhakate@mail.nplindia.org

Abstract


The objective of the present investigation is to deliver antiemetic GH (Granisetron hydrochloride) drug to cancer patient through nanofibers transdermal patch to overcome the problem of chemotherapy induced post-operative side effects like nausea and vomiting. The biodegradable poly vinylalcohol (PVA) and polyvinyl pyrrolidone (PVP) electrospun composite nanofiber based transdermal patch was developed and anti-emetic drug was loaded by active loading in it. The in-vitro drug release from nanofibers patch demonstrates that there is a controlled release pattern of the drug and release rate is varying with PVP content in the composite nanofiber patch. Also from the data of cumulative drug permeation and steady state flux demonstrates that rate of drug release through membrane and permeation across skin increases with increasing concentration of PVP. The drug release follows Higuchi model of kinetics. While marketed drug tablet follows the zero order kinetic model of drug release. The regression values obtained for both the formulations lie in the range of 0.9484 – 0.951 which suggests the mechanism of drug release is due to the diffusion of embedded drug molecule and erosion of polymer from nanofiber an aqueous medium. Thus the present investigation gives impetus to work in the direction of delivering anti-emetic drug through nanofibers transdermal patch.

Keywords

Electrospinning, nanofibers, granisetronhdrochloride, in vitro control release.

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