S. Malathi1, M. D. Balakumaran2, P. T. Kalaichelvan2, S. Balasubramanian1
1Department of Inorganic Chemistry, University of Madras, Chennai, India
2CAS in Botany, University of Madras, Chennai, India
Adv. Mater. Lett., 2013, 4 (12), pp 933-940
DOI: 10.5185/amlett.2013.5477
Publication Date (Web): Nov 24, 2013
Copyright © 2019 VBRI Press
E-mail: bala2010@yahoo.com
Gold nanoparticles (AuNPs) have been synthesized by green method using chitosan as a reducing/capping agent. We designed a biocompatible carrier for controlled release of hydrophobic drugs. The designed carrier was prepared by using single oil-in-water (O/W) emulsion. The resulting AuNPs were characterized by UV–Vis spectroscopy (UV–Vis) and Fourier transform infrared spectroscopy (FTIR). The transmission electron microscopy (TEM) studies indicate the spherical nature of drug loaded nanoparticles with the size of 50nm while the average particle size of AuNPs is found to be 2-3nm. The chitosan capped AuNPs showed a surface plasmon resonance at 526nm. The FTIR spectra suggest that the amine group is mainly responsible for the reduction of tetrachloroauric acid and capping the AuNPs. The controlled release of rifampicin (RIF) was investigated by in vitro studies using phosphate buffer saline (PBS) at pH=7.4. The loading efficiency of drug molecule was found to be 71%. The encapsulated drugs were released at 37 °C temperature. The results have been fit into various mechanistic models and it is found that the Higuchi model fits in to the release behavior of RIF. Further, the antibacterial activity of RIF loaded nanoparticles was examined by Gram +ve (bacillus subtils) and Gram -ve (Pseudomonas aeruginosa) bacteria. The application of similar drug loaded nanocarrier for treating other diseases like cancer can also be investigated.
Cloud Medicine set to Revolutionize Doorstep Personalized Healthcare
Various surfactants for 0 – 3 dimensional nanocarbons: Separation, exfoliation and solubilization
Polypyrrole based biofunctional composite layer for bioelectrocatalytic device system
Innovative Graphene-PDMS sensors for aerospace applications
Effect of hot drawing process and carbonization temperature in electrochemical behavior of electrospun carbon nanofibers
Chemical Reactivity and Electronical Properties of Graphene and Reduced Graphene Oxide on Different Substrates
Laser Raman micro-spectroscopy as an effective non-destructive method of detection and identification of various sp2 carbon modifications in industry and in nature
Electrochemical promotion of ammonia synthesis with proton-conducting solid oxide fuel cells
Biomimetic surfaces with hierarchical structure using microsized texture and nanosized Cu particles for superhydrophobicity
Enhancement the properties of high and low-density polyethylene membranes by radiation grafting process
Synthesis of 9-Aminoacridine and its Application as an Anode Material for Aqueous Rechargeable Lithium–ion Batteries
Facile synthesis of novel tough and highly flexible biodegradable membranes for water microfiltration
Investigating the possibility of using acetic acid in place of HF in chromium-benzenedicarboxylates (MIL-53 and MIL-101) synthesis applicable for CO2 adsorption
Smart Healthcare pulls up Clouds for Virtual Medicine
Selecting the correct electromagnetic inspection technology
Influence of railway-track grinding on the track material condition and tribological behaviour
Micromechanical Fatigue Modelling of the Size Effect in Micro-Scale 316L Stainless Steel Specimens
Functionalization of Graphene and Reduced Graphene Oxide in Different Matrices
Effect of parasitic polytypes on ballistic electron transport in chemical vapor deposition grown 6H-SiC epitaxial layers
Photomemristive heterostructures based on two-dimensional crystals
Architecture - behaviour - properties relationship in Star-shaped MPA-PMMA and MPA-PS hyper-branched copolymers
Graphene and doped graphene: A comparative DFT study
Ag2CO3 / Magnetic reduced graphene oxide nanocomposite as advanced visible light photocatalytic hybrid materials for efficient degradation of azo dye
Optimization of acid hydrolysis process for the preparation cellulose nanofibrils
Alginate/k-carrageenan and alginate/gelatin composite hydrogel beads for controlled drug release of curcumin
Study of microstructure and mechanical properties of friction stir welded ferrite-martensite DP700 steel
Copyright ©2010-2019 VBRI Press
Full Article