Design and evaluation of The MOSFET type glucose biosensing system

Yoshiaki Hirano1*, Katsutoshi Ooe2, Kazuyoshi Tsuchiya3, Tomohiro Hosokawa4, Kazuto Koike5, Shigehiko Sasa6

1Department of Chemistry and Material Engineering, Kansai University, 3-3-35 Yamate-cho, Suita, Osaka, 564-8680, Japan

2Department of Mechanical Systems Engineering, Daiichi Institute of Technology, Japan

3Department of Precision Engineering, Tokai University, Japan

4Department of Applied Chemistry, Osaka Institute of Technology, Japan

5Department of Electronics, Information and Communication Engineering, Osaka Institute of Technology, Japan

6Department of Electrical and Electronic Engineering, Osaka Institute of Technology, Japan

Adv. Mater. Lett., 2013, Current Issue, 4 (2), pp 108-114

DOI: 10.5185/amlett.2012.6367

Publication Date (Web): Dec 09, 2012

E-mail: yhirano@kansai-u.ac.jp

Abstract


A health monitoring system (HMS) involving a blood extraction device with a new type of hybrid biosensor comprising an enzyme and a semiconductor has recently been developed. A MOSFET was used as the transducer. The gate electrode was extracted from the MOSFET using a cable. Gold (Au)-plate-immobilized glucose oxidase (Go) was used as a biosensor and attached to the gate electrode. Go was immobilized on a self-assembled spacer combined with an Au electrode by the cross-link method using BSA as an additional bonding material. The electrode could be used to detect electrons generated by the oxidization of hydrogen peroxide produced by the reaction between Go and glucose using the constant electric current measurement system of the MOSFET-type hybrid biosensor. The sensitivities for the diluted whole blood and blood plasma were 61.4 and 171.2 V/(mol/L), respectively. The hybrid biosensor was useful for HMS.

Keywords

MOSFET, micro-electro-mechanical systems, glucose biosensor

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