1College of Life Science and Technology, Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, P.R. China
2Cranfield Health, Vincent Building, Cranfield University, Cranfield, Bedfordshire, MK43 0AL, UK
Adv. Mater. Lett., 2012, 3 (4), pp 293-296
DOI: 10.5185/amlett.2011.4235
Publication Date (Web): Jul 22, 2012
Copyright © IAAM-VBRI Press
E-mail: s.wang@cranfield.ac.uk
A nanoscale optical fiber probe with proper tailored tip diameter, taper angle and taper length is essential to monitor biological phenomena in single cells. In this work, F-MCC-T optical fiber, a multimode optical fiber with good propagating property within UV-Vis range is selected to fabricate the nanoprobe by pulling method. The method, particularly the factors affecting the tip diameter, taper angle and the taper length were thoroughly studied. Results show that optimal conditions could produce a nanoscale probe with a 50 nm of diameter, 6000 nm of taper length and taper angle of 28 degree with good reproducibility.
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