Inhibitive Effect on the Rate of Hydrolysis of Tetracaine by the Surfactant-Coated Magnetic Nanoparticles (Fe3O4)

Department of Applied Chemistry, Z.H. College of Engineering and Technology, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India 

E-mail: drrafiquee@gmail.com

Adv. Mater. Lett., 2021, 12 (4), 21041619

DOI: 10.5185/amlett.2021.041619

Publication Date (Web): Feb 01, 2021

Copyright © IAAM-VBRI Press

Abstract

The influence of the magnetic nanoparticles Fe₃O₄ and surfactant coated nanoparticles on the rate of alkaline hydrolysis of tetracaine were investigated spectrophotometrically. The Fe₃O₄ nanoparticles were synthesized by co-precipitation method. These synthesized nanoparticles were characterized by physical techniques. The XRD patterns showed the crystalline nature and the presence of two bands at 635 cm^-1 and 585 cm^-1 were assigned to the Fe-O bond vibrations in Fe₃O₄. The SEM and TEM studies confirmed the spherical structure of nanoparticles. The VSM studies show the magnetic nature. The reaction rate increased linearly with increase in [NaOH]. The rate constant values decreased with the increase in the SDS coated Fe₃O₄ nanoparticles from 4.0 × 10^-4 s^-1 to 1.1 × 10^-4 s^-1 in the presence of PEG 1500. Similarly, the increase in the amount of CTABr coated Fe₃O₄ nanoparticles decreased the rate constant values from 4.0 × 10^-4 s^-1 to 1.02 × 10^-4 s^-1 in the presence of PEG 1500. The binding constant and rate constant were found to be lower in SDS coated nanoparticles than the CTABr coated particles. The observed results for - [surfactant] in the presence of magnetic nanoparticles and surfactant coated nanoparticles were treated using the pseudophase kinetic model.

Keywords

Base catalysed hydrolysis of tetracaine, Fe₃O₄ magnetic nanoparticles, SDS@Fe₃O₄, CTABr@Fe₃O₄