Evaluation of Drug Interactions with Medications Prescribed to Ambulatory Patients with Metabolic Syndrome in Urban Area

Kayamkani Abedulla Khan1,*, Ali Mohamed AlKatsha1, Mohammed Abdulghani Sarhan1, Fawaz Mashaan Abuhamar1, Rawaf Abdulrzaq1, Aejaz A. Khan2, S. M. Shakeel Iqubal2, Muazzam Sheriff Maqbul3

1Department of Clinical Pharmacy & Pharmacology, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia

2Department of General Sciences, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia

3Faculty of Microbiology and Immunology, Ibn Sina National College of Medical Sciences, Al Mahajar Street: 31906, Jeddah 21418, Kingdom of Saudi Arabia

Adv. Mater. Lett., 2020, 11 (3), 20031487 (1-4)

DOI: 10.5185/amlett.2020.031487

Publication Date (Web): Feb 26, 2020

E-mail: abidulla.k@gmail.com

Abstract


This study is planned to assess the profile of drug-drug interactions in the medications prescribed to metabolic syndrome patients and also to identify the possible predictors for potential drug-drug interactions.

Materials and Methods: A cross-sectional study was conducted from 25th Jan to 1st April 2019 to check the drug interactions in ambulatory metabolic syndrome patients in Jeddah, Saudi Arabia. A sample size of 142 patients was included in the study. The prescriptions were analyzed for potential drug interactions using Lexi-Interact Online and Medscape online software to check drug-drug interactions.

Results: It is observed that as an average 3.85 drug per prescription was prescribed. We observed 55 prescriptions are containing incomplete patient information that is 48.6% of prescriptions. The 62% of patients of this study were more than 60 years. We found a maximum number of prescriptions were found 4-6 drugs per prescription 60.56 % and 78.12 % interactions were moderate interaction and 3.9 % interaction found were major interactions.

Conclusion: It was observed that the number of DDIs increased linearly with the number of drugs and age. The majority of interactions was pharmacodynamic in mechanism and showed moderate severity.

Keywords

Drug interactions, ambulatory patients, metabolic syndrome

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