1Department of General Science, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia
2Department of Pharmaceutical Science, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia
Adv. Mater. Lett., 2020, 11 (2), 20021476
Publication Date (Web): Jan 27, 2020
Copyright © IAAM-VBRI Press
Anisoles and Pyridines undergo acetylation and formylation under non-classical Vilsmeier-Haack conditions. The reactants are grinded vigorously in a mortar for about 25 to 30 min at room temperature with a pestle. The introduction of formyl and acetyl groups under solvent free conditions is a unique, fast and efficient method which has not been reported in literature so far.
Vilsmeier-Haack reaction, anisoles, pyridines, dimethylformamide, dimethylacetamide.