Vilsmeier-Haack Transformations under Non Classical Conditions

Tasneem Mohammed1,*, Aejaz A. Khan1, S. M. Shakeel Iqubal1, Touseef Begum2

1Department of General Science, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia
2Department of Pharmaceutical Science, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia

Adv. Mater. Lett., 2020, 11 (2), 20021476

DOI: 10.5185/amlett.2020.021476

Publication Date (Web): Jan 27, 2020

E-mail: drtasneem1431@gmail.com

Abstract


Anisoles and Pyridines undergo acetylation and formylation under non-classical Vilsmeier-Haack conditions. The reactants are grinded vigorously in a mortar for about 25 to 30 min at room temperature with a pestle. The introduction of formyl and acetyl groups under solvent free conditions is a unique, fast and efficient method which has not been reported in literature so far.

 

Keywords

Vilsmeier-Haack reaction, anisoles, pyridines, dimethylformamide, dimethylacetamide.

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