Organic Montmorillonite Intercalated Nano-composites Prevent Post-Surgical Associated Infections

Zahra Rezvani1, Mazaher Gholipourmalekabadi2, Saeid Kargozar3, Peiman Brouki Milan2, Masoud Mozafari2,*

1Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Milano, Italy

2Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

3Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine,
Mashhad University of Medical Sciences, Mashhad, Iran

Adv. Mater. Lett., 2020, 11 (2), 20021471

DOI: 10.5185/amlett.2020.021471

Publication Date (Web): Jan 27, 2020



In this study, organic montmorillonite (OMMT) is a modified form of montmorillonite (MMT) in which chitosan (CS) intercalated MMT by ion exchange of sodium ions from Na/MMT with –NH3+ of CS. The structural analysis confirmed intercalation of CS into MMT layers, indicating that CS molecular chains incorporated into the MMT layers. The interlayer distance of the MMT layered was 1.128nm and in the OMMT layers enlarged to 2.365 nm. Antibacterial activity analysis showed that unmodified MMT could not inhibit the growth of bacteria. Nevertheless, after addition of the CS molecules, an increase in the interlayer distance of MMT was observed. No difference was observed between the viability of the human dental pulp stem cells (hDPSCs) contacted to different concentrations (ranging from 0.5 to 2mg/ml) of MMT and OMMT in all time intervals, when compared with the control samples. Furthermore, neither MMT nor OMMT showed apoptosis and cytotoxicity effect on the cells. The strong antibacterial activity of the synthesized OMMT nanocomposite was also confirmed against E. coli, S. aureus, K. pneumonia and P. aeruginosa, suggesting its high potential for the prevention of post-surgical infections.


Montmorillonite, microstructure, post-surgical infections, tissue engineering.

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