The cover photo of July 2019 issue is dedicated to the 41st anniversary of the first reported synthetic approach of dendritic hyperbranched structure. The cover photo adopted from the Valer et al., where they reported the preparation of dendritic hyperbranched copolymers based on bis(hydroxyl methyl) propionic acid polyester and studied the architecture - behavior - properties relationship. Dendritic structures are known for their perfect chemical definition, highly dense structure, and a well-defined number of surface functionalities. The soft multifunctional modifications could be compliant to valuable flexibility for embedding different chemical moieties on the surface either within the structure or at the core.
Alginate/k-carrageenan and alginate/gelatin composite hydrogel beads for controlled drug release of curcumin
Sayeesh P M, Reshma Joy, Nibisha Pradeep, Franklin John*, Jinu George*
Biotechnology Laboratory, Department of Chemistry, Sacred Heart College, Kochi 682013, India
Adv. Mater. Lett., 2019, 10 (7), pp 508-514
Publication Date (Web): Jan 14, 2019
Copyright © 2019 VBRI Press
Hydrogel beads based on natural polymers like alginate, κ-Carrageenan, and gelatin represent an efficient scaffold for controlled hydrophobic drug delivery. We report herein the development and characterization different formulations of hydrogel systems based on the above-mentioned polymers having adequate properties as drug delivery matrices. Different combinations of alginate/κ-Carrageenan and alginate/gelatin hydrogel beads were developed and drug release properties were compared using curcumin as a model drug. Alginate/κ-Carrageenan hydrogel beads with 50:50 weight ratio exhibited higher swelling and better drug release percentage than compared to other beads. Antibacterial activity of curcumin released from hydrogel beads against B. cereus was established by disc assay. Encapsulation efficiency and drug release behaviour of different formulations of alginate/κ-Carrageenan and alginate/gelatin indicates that the polymer blends synthesized possess considerable potential in pharmaceutical and medicinal applications. © VBRI Press.
Hydrogel, curcumin encapsulation, antibacterial.