Graphene has emerged as the most popular subject area in the active research field since its discovery in 2004. The published documents illustrate the popularity of Graphene research and innovations, spontaneously increased from about 150 in 2004 to 21,500 in 2018. Graphene is relatively young but high-hope for markets. The cover photo of May 2019 issue describes the structure of a cylindrical Graphene to celebrate the 15th anniversary of it's discovery.
Riboflavin-UVA gelatin crosslinking: Design of a biocompatible and thermo-responsive biomaterial with enhanced mechanical properties for tissue engineering
Juan Manuel Galdopórpora1, Claudio Javier Perez2, María Victoria Tuttolomondo1, Martín Federico Desimone1*
1Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET),Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Junín 956 Piso 3◦, Buenos Aires, 1113, Argentina
2Instituto en Investigaciones en Ciencia y Tecnología de Materiales, Universidad de Mar del Plata, (CONICET), Juan B. Justo 4302, Mar del Plata, 7606, Argentina
Adv. Mater. Lett., 2019, 10 (5), pp 324-328
Publication Date (Web): Jan 14, 2019
Copyright © 2019 VBRI Press
The main objective of this study is to develop an economic, environmentally friendly and malleable biomaterial for tissue engineering applications. Water and glycerol have been used as solvents for the gelatin hydrogel synthesis. This solvent mixture led to a biomaterial with improved thermal properties. Indeed, a 16°C increase in thermal transition temperature was achieved. Furthermore, to enhance mechanical properties, riboflavin was used as a crosslinking agent. Chemical crosslinking step was initiated with UV radiation to obtain riboflavin radical polymerization of gelatin chains, hence, rheological properties of gelatin hydrogel were improved. Thus, Gelatin-UV-Riboflavin hydrogel showed good swelling and increased mechanical properties, obtaining a novel material for drug delivery and medical purposes.
Tissue engineering, biopolymer, crosslinking.