The cover photo describes the scheme of the twin screw extruder for the preparation of thermoplastic starch (TPS). As discussed by M. Paula Guarás, this screw extrusion process is very advantageous for the preparation of TPS films with improved mechanical and water vapor absorption properties in any industrial processing line for plastic packaging products.
SPIONs and curcumin co-encapsulated mixed micelles based nanoformulation for biomedical applications
Ganeshlenin Kandasamy, Atul Sudame, Dipak Maity*
Nanomaterials Lab, Department of Mechanical Engineering, School of Engineering, Shiv Nadar University, Dadri 201314, UP, India
Adv. Mater. Lett., 2019, 10 (3), pp 185-188
Publication Date (Web): Dec 31, 2018
Copyright © 2018 VBRI Press
In this work, we have synthesized oleylamine (OM)-coated hydrophobic monodispersed SPIONs with an average particle size of ~9 nm via thermal decomposition method. The as-prepared hydrophobic SPIONs are co-encapsulated along with a drug (curcumin, Cur) within the mixed micelles based nanoformulations which is made of d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) and Pluronic F127 while keeping the TPGS:F127 ratios at 100:0, 75:25, 50:50, 25:75 and 0:100. Then, the nanoformulations are characterized for hydrodynamic size via dynamic light scattering (DLS) technique, and drug/SPIONs encapsulation efficiencies are determined via UV-vis spectroscopy. Among all the nanoformulation, the mixed micelle with 50:50 TPGS:F127 has exhibited relatively lower hydrodynamic diameter (Dh) (~ 84 nm), better encapsulation efficiencies of Cur and SPIONs (~95% / 56%), and high yield (above 90%). Moreover, morphology and encapsulation of SPIONs/Cur inside the optimized 50:50 TPGS:F127 nanoformulation is confirmed by TEM. In addition, only 10% of Cur is released during 12h time period from optimized nanoformulation indicating the sustained-release property, whereas ~68% of Cur is quickly released in free Cur experiments for the same time period. Hence, the SPIONs/Cur are efficiently co-encapsulated inside the TPGS:F127 mixed micelle based nanoformulation which could be used for further biomedical applications.
Mixed micelles, SPIONs, curcumin, drug delivery, nanoprecipitation.