Cell study of the biomimetic modifications on a CoCrMo alloy for biomedical applications

Virginia Paredes1*, 2, Emiliano Salvagni3, José María Manero2

1Department of Mechanical Engineering, Universidad del Norte, km 5 Vía Pto Colombia, Barranquilla, 081008 Colombia​

2Department of Materials Science and Metallurgy, Universidad Politécnica de Cataluña (UPC), 08028, Barcelona, Spain​

3Institute For Advanced Chemistry of Catalonia, Spanish National Research Council (IQAC-CSIC) and Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Jordi Girona, 18-26, 08034, Barcelona, Spain

Adv. Mater. Lett., 2019, 10 (3), pp 180-184

DOI: 10.5185/amlett.2019.2196

Publication Date (Web): Dec 31, 2018

E-mail: paredesv@uninorte.edu.co


The number of cells adhered and their morphology on implants are indicative of its adaptation. Accordingly, the field of cellular behavior and biomimetic modifications in inorganic materials for biomedical applications show a notable increase in scientific studies. Whence, in this study, the immobilization of peptide sequences and the biological behavior on CoCrMo alloy will be evaluated. To validate the biomimetic modifications carried out on the surfaces we were proposing as hypothesis that a higher density of biomolecules bring about better cellular response. The methodology employed included 2 stages: I) Surfaces biomimetic modification: samples were initially bio activated with nitric acid, followed samples were biofunctionalizated with APTES+Maleimide and finally peptide sequences were immobilized of surface (RGD, FHRRIKA, PHSRN RGD/FHRRIKA or RGD/PHSRN). II) To evaluate the biomimetic modification, were performed studies of cell adhesion. The techniques used for characterization were X-ray photoelectron spectroscopy (XPS), contact angle (CA), immunofluorescence, scanning electron microscope (SEM). The results indicated that samples with RGD and RGD/FHRRIKA exhibited higher number of cells adhered and also cells more spread on the surface, which suggests that they were adapted to the surface, it is demonstrated that the biomimetic modifications carried out are able to successfully induce the bone tissue repair process. 


Cell response, biomimetic modification, peptide sequences.

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