The cover photo describing the crystal structure of Na5YSi4O12 with glass-ceramic Na+ superionic conductors. As discussed by Toshinori Okura, these glass-ceramic conductors have great potential and are one of the most important groups of solid electrolytes, not only because of its practical usefulness for advanced batteries but also for its three-dimensional ionic conducting nature.
TiO2 nanoparticles induced oxidative stress mediated DNA damage in the liver of adult male Wistar rats
Dasal Vasantharaja1*, Venugopal Ramalingam1, Shanmugam Thangapandiyan2, Nagarajan Sridhar2, Gaddam Dayanand Reddy3
1Department of Zoology, Kanchi Mamunivar Centre for Post Graduate Studies (Pondicherry University), Lawspet, Puducherry 605008, India.
2Department of Zoology, Annamalai University, Annamalai Nagar 608002, Tamil Nadu, India.
3Department of Pharmacology, Siddha Central Research Institute, Chennai 600106, India.
Adv. Mater. Lett., 2019, 10 (2), pp 145-150
DOI: 10.5185/amlett.2019.1532
Publication Date (Web): Dec 19, 2018
Copyright © 2018 VBRI Press
E-mail: vasaini20@gmail.com
Nanoparticles (NPs) are extensively being used in modern life due to their distinctive properties like small size having large surface area. Titanium dioxide (TiO2) NPs are mostly used in cosmetic products, food additives, pharmaceuticals and electronics. They are capable of inducing oxidative stress in both animals and human. The intention of this study was to find out the hepatotoxic effect of TiO2 NPs on the male Wistar rats. The animals were divided in to three groups. First group received normal saline; Second group received TiO2 NPs (50 mg/kg/bw) for 14 days continuously, while third group received TiO2 NPs (100 mg/kg/bw) for the same duration. The increased levels of specific markers AST, ALT, ALP, LDH and GGT along with the TBARS, LOOH, CD and PC in the liver clearly shows the hepatotoxic action of TiO2. The hepatotoxic nature of TiO2 NPs was more evidenced by the diminished activity of antioxidant enzymes levels and also showed augmented DNA damage and fragmentation in hepatocytes. In conclusion, the data indicated that TiO2 NPs induced oxidative stress which produces hepatotoxicity in the rat liver.
Intelligent healthcare for future medicine
Review of nanoscale layered transition metal chalcogenide superconductors
Evaluation of NSAIDs antioxidant activity on lipid peroxidation in splenocyte membranes
Morphological, structural, thermal and degradation properties of polylactic acid-waxy maize starch nanocrystals based nanocomposites prepared by melt processing
Influence of surfactant on the patterning behavior of nanosilver within polyacrylamide nanogels
Cell study of the biomimetic modifications on a CoCrMo alloy for biomedical applications
SPIONs and curcumin co-encapsulated mixed micelles based nanoformulation for biomedical applications
Fabrication of Y2O3 coatings by cold-spray
Triclinic LiVPO4F/C cathode for aqueous rechargeable lithium-ion batteries
PRAP-CVD: Up-scalable process for the deposition of PEDOT thin films
Effect of storage time, plasticizer formulation and extrusion parameters on the performance of thermoplastic starch films
Effect of silver nanoparticles on the ammonia gas sensing behavior in diphenylamine based conjugated polymer
Study the possibility of using sisal fibres in building applications
Impact of digital transformation for Mass healthcare
Preparation, stabilization, and self-assembly of gold nanoparticles by Chitosan derivatives
Development of Na+ superionic conducting Na5YSi4O12-type glass-ceramics
Chances and challenges in the application of fiber metal laminates
Low temperature processed efficient and stable perovskite solar cell
Tuning Polydimethylsiloxane (PDMS) properties for biomedical applications
Molecular origin of hardening effect
Polypyrrole/MWCNT nanobiocomposite based electrochemical urease biosensor
Water vapor adsorption in silica gel for thermal energy storage application
Development of anti-bio deteriorate sustainable geopolymer by SiO2 NPs decorated ZnO NRs
Increasing the efficiency of graphene-based Schottky-barrier devices
Modification of mesoporous titanium dioxide with cobalt oxide electrocatalyst for enhanced oxygen evolution reaction
TiO2 nanoparticles induced oxidative stress mediated DNA damage in the liver of adult male Wistar rats
Copyright ©2010-2019 VBRI Press
Purchase PDF