The cover photo describes the graphical representation of a programmable microfluidic device for the capture and detection of a variety of cells and bacteria. Recently, the interest in microfluidic technology has progressed considerably since the last decade due to its advanced applications in many areas including protein biochemistry, cell culture, detection, and electromechanical systems.
Bottom-up design of hydrogels through click-chemistry modification of magnetic nanoparticles
Ilaria Meazzini, Massimo Bonini, Francesca Ridi*, Piero Baglioni
Department of Chemistry “Ugo Schiff” & CSGI, University of Florence, via della Lastruccia 3, Sesto Fiorentino (FI), 50019, Italy
Adv. Mater. Lett., 2019, 10 (6), pp 386-390
Publication Date (Web): Oct 26, 2018
Copyright © 2019 VBRI Press
The paper describes a modular approach based on click chemistry for the surface modification of magnetic oxide nanoparticles and their covalent inclusion within chemical hydrogels. As a proof of concept, we prepared cobalt ferrite nanoparticles and we modified their surfaces through the reaction with molecules bearing a carboxylic function and, alternatively, either an azide or an alkyne moiety. In the second step, the modified nanoparticles were reacted through a Huisgen 1,3-dipolar cycloaddition with a molecule bearing an unsaturated function and either an alkyne or an azide moiety, respectively. Finally, the particles were successfully copolymerized with acrylamide and N,N'-methylenebisacrylamide to obtain a magnetically responsive hydrogel. This approach could be easily extended towards any type of inorganic oxide nanoparticles and their inclusion within any radically co-polymerized hydrogel.
Polymeric nanocomposite, magnetic nanoparticles, click-chemistry, polyacrylamide gel, responsive materials.