Cover Page October-2018-Advanced Materials Letters

Advanced Materials Letters

Volume 9, Issue 10, Pages 737-747, October 2018
About Cover

The cover describes the development of nanofibers with encapsulated growth factors has been emerged as a promising approach in neo-tissues applications. The proposed nanofibrous systems provide a novel approach to both simulate the extra-cellular matrix for cell adhesion and also for localized delivery of signaling molecules and growth factors. Growth factors could be loaded into nanofibers using different techniques including physical adsorption, covalent bonding or encapsulation.


Redox-active cerium oxide based nanozyme abrogate the organophosphate mediated poisoning in mammalian cells

Kinjal D. Shah, Ragini Singh, Sanjay Singh*

Division of Biological and Life Sciences, School of Arts and Science, Central Campus, Ahmedabad University, Navrangpura, Ahmedabad 380009, Gujarat, India

Adv. Mater. Lett., 2018, 9 (10), pp 737-747

DOI: 10.5185/amlett.2018.1939

Publication Date (Web): Jul 18, 2018

E-mail: sanjay.singh@ahduni.edu.in

Abstract

Owing to the autocatalytic antioxidant activity, cerium oxide nanoparticle (CeNPs) has been extensively used in biomedical fields for treatment of neurodegenerative diseases, biosensing, and therapeutic applications. The redox-dependent interconversion between +3 and +4 oxidation states of CeNPs is suggested to be the reason of scavenging of free radical generated in the biological system. Herein we have explored the protective effect of CeNPs against the oxidative stress induced by organophosphate-based pesticide, 2,2-dichlorovinyl dimethyl phosphate (DDVP), in a normal human liver cell culture model (WRL-68). DDVP is known to cause the toxic effect in cells by inducing lipid peroxidation, cellular glutathione level depletion and DNA fragmentation by the caspase-dependent pathway. We followed the protection of cells by CeNPs against DDVP exposure using MTT and NRU assays. Exposure of DDVP to cells induced significant nuclear fragmentation, which could be avoided in cells pre-treated with CeNPs. Mechanistically, we observed that CeNPs induces an increase in cellular GSH level, which could assist in removal of excess of reactive oxygen species, generated in DDVP exposed cells, along with the superoxide dismutase (SOD)-like activity of CeNPs. The interaction study showed that there was no chemical interaction between DDVP and CeNPs, therefore, the intrinsic SOD-like activity of CeNPs was intact even in the complex cell culture media. Growing evidence suggest that excess use of DDVP could lead to the several diseases in cells/tissues, therefore our finding emphasizes that CeNPs can be used as a potent antioxidant agent to avoid the ramifications of DDVP and other commercial pesticides. 

Keywords

Nanozymes, superoxide-dismutase, organophosphate, Dichlorvos Pesticide (DDVP), antioxidant nanoparticles, oxidative stress.

Previous issues

Current Global Scenario of Electric Vehicles

Review on Detection of Phenol in Water 

Investigating the Machinability of Metallic Matrix Composites Reinforced by Carbon Nanotubes: A Review

Photocatalytic ZnO based PES Membranes for AOP Water Treatments under UV and Sunlight

Plasma Activated Water as a Source of Nitrogen for Algae Growth

Digital Light Processing (DLP) 3D Printing of Polyethylene Glycol (PEG) Biopolymer, Commercially available Ultra-High and Tough (UHT) Resin and Maghemite (γ-Fe2O3) Nanoparticles Mixture for Tissue Engineering Scaffold Application

Fabrication of Nanoparticle Embedded Polymeric Microbeads as an Efficient Drug Delivery System

Micro/Nanostructured Papers from Bagasse Pulp Reinforced by Nanofibrillated Cellulose from different Agro-Waste Sources

Structural, Optical and Magnetic Properties of Pristine, (Mn, Al) co-doped ZnO Nanocrystallites Synthesized via co-Precipitation Method

Nanosecond Laser Surface Patterning of Ti6Al4V Bio-alloy for Improved Biological Performance

Synthesis of Cu2O/Ag Composite Nanocubes with Promising Photoluminescence and Photodegradation Activity over Methylene Blue Dye

Locally available Clays of Bangladesh as a Replacement of imported Clays for Ceramic Industries 

Green Synthesis and Characterization of Silver Nanoparticles using Cassia auriculata Leaves Extract and Its Efficacy as A Potential Antibacterial and Cytotoxic Effect

Upcoming Congress

Knowledge Experience at Sea TM