The cover describes the development of nanofibers with encapsulated growth factors has been emerged as a promising approach in neo-tissues applications. The proposed nanofibrous systems provide a novel approach to both simulate the extra-cellular matrix for cell adhesion and also for localized delivery of signaling molecules and growth factors. Growth factors could be loaded into nanofibers using different techniques including physical adsorption, covalent bonding or encapsulation.
Redox-active cerium oxide based nanozyme abrogate the organophosphate mediated poisoning in mammalian cells
Kinjal D. Shah, Ragini Singh, Sanjay Singh*
Division of Biological and Life Sciences, School of Arts and Science, Central Campus, Ahmedabad University, Navrangpura, Ahmedabad 380009, Gujarat, India
Adv. Mater. Lett., 2018, 9 (10), pp 737-747
DOI: 10.5185/amlett.2018.1939
Publication Date (Web): Jul 18, 2018
Copyright © 2019 VBRI Press
E-mail: sanjay.singh@ahduni.edu.in
Owing to the autocatalytic antioxidant activity, cerium oxide nanoparticle (CeNPs) has been extensively used in biomedical fields for treatment of neurodegenerative diseases, biosensing, and therapeutic applications. The redox-dependent interconversion between +3 and +4 oxidation states of CeNPs is suggested to be the reason of scavenging of free radical generated in the biological system. Herein we have explored the protective effect of CeNPs against the oxidative stress induced by organophosphate-based pesticide, 2,2-dichlorovinyl dimethyl phosphate (DDVP), in a normal human liver cell culture model (WRL-68). DDVP is known to cause the toxic effect in cells by inducing lipid peroxidation, cellular glutathione level depletion and DNA fragmentation by the caspase-dependent pathway. We followed the protection of cells by CeNPs against DDVP exposure using MTT and NRU assays. Exposure of DDVP to cells induced significant nuclear fragmentation, which could be avoided in cells pre-treated with CeNPs. Mechanistically, we observed that CeNPs induces an increase in cellular GSH level, which could assist in removal of excess of reactive oxygen species, generated in DDVP exposed cells, along with the superoxide dismutase (SOD)-like activity of CeNPs. The interaction study showed that there was no chemical interaction between DDVP and CeNPs, therefore, the intrinsic SOD-like activity of CeNPs was intact even in the complex cell culture media. Growing evidence suggest that excess use of DDVP could lead to the several diseases in cells/tissues, therefore our finding emphasizes that CeNPs can be used as a potent antioxidant agent to avoid the ramifications of DDVP and other commercial pesticides.
Nanozymes, superoxide-dismutase, organophosphate, Dichlorvos Pesticide (DDVP), antioxidant nanoparticles, oxidative stress.
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