Cover Page August-2018-Advanced Materials Letters

Advanced Materials Letters

Volume 9, Issue 8, Article ID 590-593, August 2018
About Cover


Efficient siRNA delivery using osmotically active and biodegradable poly(ester amine)  

Jadhav N.1, Min Hye Ahn1, Jaiprakash Sangshetti2, Rohidas B. Arote1, 3*

1Department of Molecular Genetics, School of Dentistry, Seoul National University, Seoul 08826 Republic of Korea

2Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad, MH State, India

3Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, Republic of Korea 

Adv. Mater. Lett., 2018, 9 (8), pp 590-593

DOI: 10.5185/amlett.2018.2026

Publication Date (Web): Jun 14, 2018

E-mail: rohi06@snu.ac.kr

Abstract


Biodegradable and hyperbranched poly(ester amine) (PEA) was prepared by reaction of glycerol dimethacrylate (GDM) with  low molecular weight polyethylenimine (LMW-PEI) by Michael addition reaction. This novel gene carrier showed excellent physicochemical properties and relatively low cytotoxicity compared with PEI 25K. It showed excellent transfection efficiency and siRNA delivery. The higher silencing efficiency of PEAs could be attributed to the synergistic effect arising from hyperosmotic glycerol and proton sponge active PEI residues in the PEA backbone.

Keywords

Poly (ester amine), hyperosmotic effect, proton sponge effect, siRNA delivery.

Current Issue
The Journey of a Decade to Advancing Materials
Are the Electrospun Polymers Polymeric Fibers?
Mechanical and Thermal Properties of Composite Material and Insulation for a Single Walled Tank for Cryogenic Liquids
Prediction of Long-Term Behavior for Dynamically Loaded TPU
Investigation of Doped Titanium Dioxide in Anatase Phase. Study ab initio using Density Functional Theory
Comparison between Single Al2O3 or HfO2 Single Dielectric Layers and their Nanolaminated Systems
Preparation of Stable and Optimized Antibody-gold Nanoparticle Conjugates for Point of Care Test Immunoassays
Resonance-Based Temperature Sensors using a Wafer Level Vacuum Packaged SOI MEMS Process
Integrated System Based on the Hall Sensors Incorporating Compensation of the Distortions
The Efficacy of Cinnamomum Tamala as a Potential Antimicrobial Substance against the Multi-Drug Resistant Enterococcus Faecalis from Clinical Isolates
The Effect of Complexing Reagent on Structural, Electrical and Optical Properties of CuS Thin Film
Laser Cladding of Fluorapatite Nanopowders on Ti6Al4V
Preparation and Evaluation of Sulfonate Polyethylene Glycol Borate Ester as a Modifier of Functional Properties of Complex Petroleum Lithium Grease

Upcoming Congress

Knowledge Experience at Sea TM