Template-assisted fabrication of tunable aspect ratio, biocompatible iron oxide pillar arrays
Ryan Chang Tseng1, Ching-Wen Li2, Gou-Jen Wang1, 2, 3*
1Graduate Institute of Biomedical Engineering, National Chung-Hsing University, Taichung 402, Taiwan
2Department of Mechanical Engineering, National Chung-Hsing University, Taichung 402, Taiwan
3Tissue Engineering and Regenerative Medicine, National Chung-Hsing University, Taichung 402, Taiwan
Adv. Mater. Lett., 2018, 9 (4), pp 249-257
DOI: 10.5185/amlett.2018.1842
Publication Date (Web): May 17, 2018
Copyright © 2019 VBRI Press
E-mail: gjwang@dragon.nchu.edu.tw
The extensive use of iron oxide nanomaterials in biomedical applications has prompted the development of a novel substrate for evaluating cell behaviour. This study examines the fabrication of tuneable length iron oxide pillar arrays using the porous nanochannels of anodic aluminium oxide membranes, and evaluates the biocompatibility of the substrate. The electroformed iron pillars were found to conform to the template channels with slightly larger iron oxide pillar diameters, due to the presence of an oxide shell. The biocompatibility was then confirmed with WST-1 proliferation and viability assay of cultured KT98 murine neural/progenitor stem cells on the surface of the pillar array; with no significant difference observed between viable cells after seven days of culture on iron oxide pillars, flat iron oxide, and tissue culture polystyrene. The physical properties of the pillar arrays were linked to the adhesion and spreading of the cells, and found that cells cultured on the pillar arrays had reduced spreading in comparison to tissue culture polystyrene control. In addition, it was found that protein expression was unaffected by culture on iron oxide substrates. The results of this study indicate that iron oxide pillar arrays are suitable to extended cell studies.
Healthcare informatics driven nanotechnology
Brief Review: Simulation of Novel Systems Using Duality Quantum Algorithm
Significant Quality Parameters of Finishing Technology in Offset Printing on Solid Board Boxes Depending on the type of Material
Generation of entanglement in spin states of Rydberg atoms by chirped optical pulses
Matrix and Variant Transformations Simulate Statistical Canonical Ensembles from Fock to Poissonian States of Random Sequences
The Vortex Glass-Liquid Transition in Fe1.02Se Crystal
Magnetic Properties of Intercalated Gr/Ni (111) System
Functionalized Nano Carbon for excellent Microwave Absorption at GHz Frequency
Deformation Texture Modelling by Mean-Field and Full-Field Approaches
Growth, Linear and Nonlinear Optical Studies of D-Tartaric Acid Crystal
Graphene-MoS2-Au-TiO2-SiO2 Hybrid SPR Biosensor for Formalin Detection: Numerical Analysis and Development
Microstructure and Mechanical Characterization Study in the IN718/BNi-2/316L Joint by Transient Liquid Phase Bonding Process
Stress Fields at the Central Point of Arc Crack under Uniaxial Tension
Cloud Medicine set to Revolutionize Doorstep Personalized Healthcare
Various surfactants for 0 – 3 dimensional nanocarbons: Separation, exfoliation and solubilization
Polypyrrole based biofunctional composite layer for bioelectrocatalytic device system
Innovative Graphene-PDMS sensors for aerospace applications
Effect of hot drawing process and carbonization temperature in electrochemical behavior of electrospun carbon nanofibers
Chemical Reactivity and Electronical Properties of Graphene and Reduced Graphene Oxide on Different Substrates
Laser Raman micro-spectroscopy as an effective non-destructive method of detection and identification of various sp2 carbon modifications in industry and in nature
Electrochemical promotion of ammonia synthesis with proton-conducting solid oxide fuel cells
Biomimetic surfaces with hierarchical structure using microsized texture and nanosized Cu particles for superhydrophobicity
Enhancement the properties of high and low-density polyethylene membranes by radiation grafting process
Synthesis of 9-Aminoacridine and its Application as an Anode Material for Aqueous Rechargeable Lithium–ion Batteries
Facile synthesis of novel tough and highly flexible biodegradable membranes for water microfiltration
Investigating the possibility of using acetic acid in place of HF in chromium-benzenedicarboxylates (MIL-53 and MIL-101) synthesis applicable for CO2 adsorption
Copyright ©2010-2019 VBRI Press
Full Article