Selective adsorbtion of low density lipoprotein from blood using porous silicon

Praveen Kumar S*, Ramesh R, Aravind T

Department of Electronics and Communication Engineering, Saveetha Engineering College, Thandalam, Chennai 602105, Tamilnadu, India

Adv. Mater. Lett., 2018, 9 (2), pp 142-147

DOI: 10.5185/amlett.2018.1952

Publication Date (Web): May 16, 2018

E-mail: praveenkumarsunil@gmail.com

Abstract


This work presents the isolation of Low-Density Lipoprotein (LDL) from blood. The blood molecules with size less than 1µm are filtered in the size based crossflow filter technique. Filtered molecules are passed through the Porous Silicon (PSi). The immobilized Anti-Apolipoprotein B (AAB) on the surface of Porous Silicon is used to adsorb the LDL. Isolation of LDL based on Porous Silicon eliminates the calculation of the other lipoproteins and Triglycerides. Filter with AAB coated PSi is designed and simulated in COMSOL Multiphysics software. 

Keywords

Low density lipoprotein, crossflow filter, size based separation, porous silicon.

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