Biocompatible features of magnetic nano-oxide core/ PCL shell 3D composites fabricated via SLS/M process 

Igor Shishkovsky 1, 2*, Stanislav Volchkov2, Vladimir Scherbakov1, Larisa Volova2

1P.N. Lebedev Physic Institute of RAS, Samara Branch, Novo-Sadovaja st., Samara, 443011, Russia

2Samara State Medical University, Chapaevskaja St., Samara, 443096, Russia

Adv. Mater. Lett., 2018, 9 (1), pp 31-35

DOI: 10.5185/amlett.2018.1676

Publication Date (Web): May 15, 2018

E-mail: igor.szyszkowski@fian.smr.ru

Abstract


Superparamagnetic oxide nanoparticles attract increasing attention in biomedical applications for tagging, imaging, separation and/or purification of cancer cells in living tissue. At the present study the selective laser sintering/melting (SLS/M) process using the Nd+3YAG laser was carried out to fabricate and characterize polymer composites based on nano-oxides of FexOy type or of high-temperature superconductivity (HTS) of SrFe12O19 with bioresorbable polycaprolactone (PCL) powders and manufacture porous tissue engineering scaffolds. Practicability of the method for synthesis of functional-gradient three dimensional (3D) parts with magnetic nano-oxide particles and structural ordering were shown and appropriated laser regimes were assigned. The stem cellular morphometry, proliferative and adhesive activity to the 3D magnetic nanocomposites were compared. The medical tests show that all the 3D printed composites have biocompatible features. Medical potential of the SLS/M-fabricated superparamagnetic nano oxides for application as cell targeting systems and tissue engineering scaffolds is being discussed.

Keywords

Selective laser sintering/melting (SLS/M), superparamagnetic oxides, high-temperature superconductivity (HTS), functional gradient nanocomposites, polycaprolactone (PCL), multipotent mesenchymal stem cells (MMSC), scaffolds.

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