Gold nanoparticle-based biosensors for the assay of tumor marker proteins with clinical applications

Jiehua Ma1, 2, Xiaolu Hu1, Yaqin Tao1, Chao Li1, Xiaoxia Mao3, Genxi Li1, 3*

1State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, Department of Biochemistry, Nanjing University, Nanjing 210093, P. R. China

2State Key Laboratory of Reproductive Medicine, Department of Reproductive Health, Nanjing Maternity and Child Health Care Hospital Affiliated with Nanjing Medical University, Nanjing 210004, P. R. China.

3Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University,  Shanghai 200444, P. R. China

Adv. Mater. Lett., 2017, 8 (12), pp 1125-1131

DOI: 10.5185/amlett.2017.1552

Publication Date (Web): Sep 08, 2017

E-mail: genxili@nju.edu.cn

Abstract


The detection of tumor markers plays an important role in clinical diagnosis and evaluation of therapeutic effect. Early detection of tumor markers, which are usually proteins, can greatly facilitate effective treatment with different modalities and even increase cure rate of patients. Currently, nanoparticle-based methods for cancer diagnostics are becoming an increasingly relevant alternative to traditional techniques. Gold nanoparticles (AuNPs) are one of the most extensively studied nanomaterials due to their remarkable physical and chemical properties. With the recent advances in nanotechnology, AuNPs have offered new ways to detect tumor markers at low concentrations and to target cancer cells in very deep sites. The use of AuNPs may increase the sensitivity of a biosensor and generate higher accuracy and precision of the assays. So, AuNPs have greatly facilitated the development of nanomaterials-based technology for clinic diagnostics and therapy. In this review paper, we have summarized different kinds of AuNPs-based biosensors for the detection of tumor marker proteins with a particular focus on optical and electrochemical techniques, which may provide valuable perspective for the colleagues in the related communities.

Keywords

Gold nanoparticles, biosensors, tumor marker protein, colorimetric analysis, electrochemical analysis.

Previous issues

Celebrating 10th Years of Diamond Open Access Publishing in Advanced Materials  

Cerebral Oxygenation Studies Through Near Infrared Spectroscopy: A Review

Analysis of Fine Sulfoaluminate Cement by Strength and Thermogravimetric Analysis

Characterization of the Interfacial Surface Energy for Composite Electrical Conduction Measurements using Two Full Range Percolation Threshold Models

Quantitative Detect of Fatigue of Membrane of Erythrocyte in Uniform Shear Field

Ecofriendly-developed Polyacrylic Acid-coated Magnetic Nanoparticles as Catalysts in Photo-fenton Processes

Evaluation of Drug Interactions with Medications Prescribed to Ambulatory Patients with Metabolic Syndrome in Urban Area

Fiber-reinforced Cementitious Composite: Sensitivity Analysis and Parameter Identification 

Evaluation of Drug Utilization Patterns Based on World Health Organization Drug use Indicators at Outpatients Clinics

Are Quantitatively Micro-machined Scaffolds Effective for Cell Technology?

Synthesis and Characterization of Gold Nanoparticles from Lobelia Nicotianifolia Leaf Extract and its Biological Activities

Advanced Oxidations of Tartrazine Azo-dye

Antifungal Activity of Salvia jordanii Against the Oral Thrush Caused by the Cosmopolitan Yeast Candida albicans among Elderly Diabetic Type 2 patients

Upcoming Congress

Knowledge Experience at Sea TM