Composite BME-AuNPs: Chemopreventive effect on skin carcinoma and inhibition on leukemia blood cancer cells

Ramesh Gunti1, Gangappa Dharmapuri2, Sumanjoshi Doddapaneni3, Chander Amgoth4*

1Departmentof pharmacology, K. L. E. S College of Pharmacy, Hubli, Karnataka, 580 031, India

2Deparment of Animal Biology, School of life Sciences, University of Hyderabad, 500 046, India

3Deparment of Biochemistry, Acharya Nagarjuna University, Andhra Pradesh, 522 510, India

4School of Engineering Sciences and Technology, University of Hyderabad, Hyderabad, 500 046, India

Adv. Mater. Lett., 2017, 8 (11), pp 1057-1064

DOI: 10.5185/amlett.2017.1733

Publication Date (Web): Aug 05, 2017

E-mail: chander@uohyd.ac.in

Abstract


Herein, the chemopreventive effect of oral and topical administration of composite of alcoholic plant extracts of Butea monosperma (Lam.) Taub. (BME) leaves and gold nanoparticles (Au NPs) have been investigated. The tumor growth has been initiated by the 7, 12-dimethyl benz (a) anthracene (DMBA) and skin tumorigenesis in male Swiss albino mice were promoted by the 12-O-tetradecanoylphorbol-13-acetate (TPA). However, malignant feature of the skin tumors were treated with composite of (BME-Au NPs) to reduce the tumor incidence, tumor burden, tumor yield, cumulative number of tumors, tumor size, mass, and volume, respectively. Furthermore, studies were extended to treat CML (chronic myeloid leukemia) K562 (blood cancer) cells with the combination of DMBA/TPA-(BME-Au NPs) and it show greater (~80%) cellular inhibition on cancer cells. Compare to BME alone the composite of (BME-Au NPs) shows significant effect on skin carcinoma and as well on cancer cells. 

Keywords

Chemopreventive, plant extract, composite, cell inhibition, skin carcinoma.

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