ATA and TA coated superparamagnetic iron oxide nanoparticles: Promising candidates for magnetic hyperthermia therapy

Ganeshlenin Kandasamy, Atul Sudame, Dipak Maity*

Nanomaterials Lab, Department of Mechanical Engineering, School of Engineering, Shiv Nadar University, Dadri -201314, UP, India

Adv. Mater. Lett., 2017, 8 (8), pp 873-877

DOI: 10.5185/amlett.2017.1730

Publication Date (Web): May 23, 2017



In recent times, superparamagnetic iron oxide nanoparticles (SPIONs) are widely used as heating agents in magnetic hyperthermia therapy (MHT) to kill malignant cells in cancer treatments, which is mainly due to their excellent magnetic properties and biocompatibility. However, it is still a challenge to coat SPIONs with suitable surfactants and to apply an appropriate alternative magnetic field (AMF) at specific frequency to achieve enhanced heating effects in MHT. In this work, the as-synthesized novel short-chain surfactants (i.e., amino-terephthalic acid (ATA) and terephthalic acid (TA)) coated hydrophilic SPIONs are synthesized and subsequently involved in calorimetric hyperthermia studies to investigate their intrinsic heating capability by varying (i) their concentrations from 1 - 8 mgFe/ml and (ii) AMFs at different frequencies (263.2 – 752.39 kHz) while achieving the temperature above 42 °C – therapeutic hyperthermia temperature. It is found that the heating rate of TA-SPIONs is faster as compared to ATA-SPIONs on exposure to the AMF. However, the highest specific absorption rate (SAR) value of 129.80 W/gFe is attained for ATA-SPIONs with 2 mgFe/ml concentration on exposure to AMF at 752.39 kHz. Thus, ATA/TA coated SPIONs are very promising agents for magnetic hyperthermia and could be further investigated in in vitro/in vivo cancer treatments.


Terephthalic acid, amino-terephthalic acid, hydrophilic SPIONs, magnetic hyperthermia, specific absorption rate

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