Cover Page April-2017-Advanced Materials Letters

Advanced Materials Letters

Volume 8, Issue 4, Pages 531-541, April 2017
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Electrochemical nanobiosensor for real-time detection of gap junction-mediated intercellular communication activity

Halina V. Grushevskaya1, Nina G. Krylova1*, Igor V. Lipnevich1, Taisija I. Orekhovskaja2,  Boris G. Shulitski2

1Belarusian State University, 4 Nezavisimosti Ave., Minsk, 220030, Belarus

2Belarusian State University of Informatics and Radioelectronics, 6 P. Brovki Str., Minsk, 220013, Belarus

Adv. Mater. Lett., 2017, 8 (4), pp 531-541

DOI: 10.5185/amlett.2017.7092

Publication Date (Web): Mar 15, 2017

E-mail: krylovang@bsu.by

Abstract

A capacitive nanobiosensor which consists of multiwalled carbon nanotubes (MWCNTs) covered by conducting oligomer of thiophene-pyrrole derivatives was constructed and fabricated to detect the gap junction-mediated communication between living cells in a monolayer. The sensor operates on screening and spin-dependent polarization effects in nanoheterostructures which present themselves MWCNTs decorated by organometallic complexes of high-spin Fe(II) and are fabricated by a Langmuir-Blodgett (LB) technique. The nanoheterostructures were deposited on transducer, which is an interdigital electrode system covered by a dielectric layer. As the cell monolayer density increased while the cells proliferated on the sensor surface, the sensor capacity decreased until the cell monolayer was confluent. This decrement is due to a forming network of the open gap junction channels (GJCs) in accordance with an electrochemical analysis performed. The monolayer capacity increases when adding GJC inhibitor (carbenoxolone) which leads to decrease of a number of the open GJCs. The technique has been used in real-time regime to establish some principles of menadione-mediated GJC-network fine-tuning. Menadione causes Ca2+-dependent GJ channels opening/closing.

Keywords

Impedance analysis, intercellular communication, gap junction channel, nanobiosensor.

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