State of Art Review on Nanobubbles

State of Art Review on Nanobubbles

Ajinkya Kailas Pote1, Pooja Jayram Jadhav2, Vishal Vijay Pande3,*, Mahendra Ashok Giri4, Shubham Rameshrao Pandit2

1Department of Pharmaceutics, Rajarshi Shahu College of Pharmacy, Buldana, Maharashtra 443001, India

2Department of Pharmaceutics (PG), Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra 423603, India

3R.S. M’s N.N Sattha College of Pharmacy, Ahmednagar, Maharashtra, India

4Department of Pharmacology, Rajarshi Shahu College of Pharmacy, Buldana, Maharashtra 443001, India

Adv. Mater. Lett., 2021, 12 (3), 21031608

DOI: 10.5185/amlett.2021.031608

Publication Date (Web): Jan 06, 2021



Nanotechnology has proved an emerging field in diagnostic in drug delivery. The current review has done special emphasis on the history of nanobubble, nomenclature, stability of nanobubble, physico-chemical properties, characterization of nanobubble, method of preparation and applications. The nanobubbles has now been explored for its antibiotic delivery, gene delivery, targeting drug delivery, anticancer drug delivery, improving cellular uptake of chemotherapy drugs into cancer cell lines. Nanobubbles (NBs) opened a new field of ultrasound imaging and used as a diagnostic method. The article explored a novel application like oxygen delivery through nanobubble which is highly beneficial in most of the diseases.


Nanobubble, oxygen delivery, ultrasound, theranostic

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