Biomineralization; hydroxyapatite; polymer fasciculus; biomimetic synthesis

A Facile Fabrication Of Hydroxyapatite In Vitro Using Polymer Fasciculus As Biotemplate Carrier

Tao Yan, Dong  Wei, Xianpeng Zheng, Xiaodong Xin, Nuo Zhang,  Dan Wu, Liangguo Yan, He Li, Bin Du*, Qin Wei*

Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China

Adv. Mater. Lett., 2010, 1 (2), pp 106-113

DOI: 10.5185/amlett.2010.4111

Publication Date (Web): Apr 08, 2012

E-mail: ,


For biomimetic synthesis of hydroxyapatite by simulating biomineralization, the polyamide 66 (PA 66) was used as biotemplate carrier, and the biotemplate was prepared by the adsorption of AOT surfactants at interfaces of polymer fasciculus. Simulating biomineralization was carried out at physiological condition (pH = 7.4, T = 37 oC). The phase components, morphologies and possible growth mechanism of calcium phosphate were studied by fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The results indicated that the course of crystal growth, as well as the morphology and composition of product was markedly dependent on biotemplate; the crystals size were within nanometer scope, with a sphere and short rod-like shape extraordinary close to natural bone. The possible mechanism of crystal growth was discussed.


Biomineralization, hydroxyapatite, polymer fasciculus, biomimetic synthesis

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