Easy-Synthesis of BDA/ABDA Functionalized Hydrophilic Superparamagnetic Iron Oxide Nanoparticles for Magnetic-Hyperthermia Application

Ganeshlenin Kandasamy1,2, Atul Sudame2, Dipak Maity3,*

1Department of Biomedical Engineering, Vel Tech Rangarajan Dr. Sagunthala R&D Institute of Science and Technology, Chennai, Tamil Nadu, India

2Department of Mechanical Engineering, Shiv Nadar University, Dadri, Uttar Pradesh, India

3Department of Chemical Engineering, Institute of Chemical Technology, IndianOil Odisha Campus, Bhubaneswar, Odisha, India

Adv. Mater. Lett., 2020, 11 (9), 20091558

DOI: 10.5185/amlett.2020.091558

Publication Date (Web): Aug 07, 2020

E-mail: dipakmaity@gmail.com


Herein, we have reported an easy process for the synthesis of superparamagnetic iron oxide nanoparticles (SPIOs, with a size of ~ 10 nm), where these SPIOs are surface-functionalized with novel pi-electron rich surfactants such as 1,4-benzene dicarboxylic acid (BDA) and 2-amino-1,4-benzene dicarboxylic acid (ABDA). The BDA/ABDA capped SPIOs have demonstrated well crystalline character, excellent colloidal stability, and high saturation magnetization. Moreover, these capped SPIOs have shown good heating ability in magnetic-hyperthermia studies under an alternating magnetic field at a medically suitable frequency, as compared to the previously reported SPIOs based heating-agents. Thus, the as-prepared BDA/ABDA-SPIOs can be used as promising heating agents for magnetic-hyperthermia based biomedical applications.


Ferrofluids, biomedical applications, magnetic hyperthermia, superparamagnetic nanoparticles.

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