COVID-19: A Mechanistic Approach to Understand the Detrimental Consequences for Vaccine Development and Perspectives

Chander Amgoth1,*, Tirupathi Malavath2, Guping Tang1,*

1Department of Chemistry, Zhejiang University, Hangzhou-310028, China

2Department of Biochemistry and Molecular Biology, Tel Aviv University, Israel

Adv. Mater. Lett., 2020, 11 (9), 20091551

DOI: 10.5185/amlett.2020.091551

Publication Date (Web): Aug 07, 2020

E-mail: chander@uohyd.ac.in (C.A.); tangguping@zju.edu.cn (G.T.)

Abstract


Herein, the mechanistic approach to understanding the characteristic properties of the deadliest virus (COVID-19) has been corroborated. The nano-sized (160-200 nm, in diameter) virus along with the crucial role of spikes (length ~10 nm) has been deliberated. The distorted protein envelope followed by the amino-acid sequence mismatching lead to replicate the virus. Fragmented ssRNA further make duplicate template copies through the mutations for net-work entanglement. Mutations lead to an increase in population density of virus uncountable. Drastic increase in the virus shows an adverse effect on the immune system. The inflamed sacs of lungs will not allow the exchange of gases and ultimately lead to pneumonia/SARS-CoV2 (severe acute respiratory syndrome of coronavirus). The glycoprotein of spike spindles fuses the surface of lung cells through the binding affinity and slowdown the activity of antibodies. Inflammation caused because of the replicated complex of virus blocks the passage of gases O2, CO2 which lead to severe cough and respiratory problems. This unusual phenomenon of pneumonia leads to death. Further, massive computing is needed to understand the exact detrimental consequences of COVID-19 followed by the drug and vaccine development.

Keywords

Spikes, net-work formation, mutations, detrimental, pneumonia, inflammation.

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