The Efficacy of Cinnamomum Tamala as a Potential Antimicrobial Substance against the Multi-Drug Resistant Enterococcus Faecalis from Clinical Isolates

Muazzam Sheriff Maqbul1, Aejaz A. Khan2, Tasneem Mohammed2, S.M. Shakeel Iqubal2,*, Abdul Rahman Ikbal2, Ibrahim Ahmed Shaikh3, Uday Muddapur4, Mohammed Shahid Hussain5, S. K. Singh6

1Faculty of Microbiology and Immunology, Ibn Sina National College of Medical Sciences, Al Mahjar Street: 31906, Jeddah 21418, Kingdom of Saudi Arabia

2Department of General Science, Ibn Sina National College of Medical Sciences, Al Mahajar Street: 31906, Jeddah 21418, Kingdom of Saudi Arabia

3Department of Pharmacology, College of Pharmacy, Najran University, Najran, Saudi Arabia

4Department of Biotechnology, KLE Technological University, BVB Campus, Hubballi, 580031, India

5Department of Orthodontics and Dentofacial Orthopedics, M. A. Rangoonwala Dental College, Pune, Maharashtra, India

6Department of Chemistry, GGV (Central University), Bilaspur (C.G) 495009, India

Adv. Mater. Lett., 2020, 11 (1), 20011464 (1-4)

DOI: 10.5185/amlett.2020.011464

Publication Date (Web): Jan 06, 2020

E-mail: shakeeliqubal@gmail.com

Abstract


The present study showcases the efficacy of Cinnamomum tamala (C. tamala) as a potential antimicrobial substance against the multi-drug resistant Enterococcus faecalis (E. faecalis) bacterium. The one of the most vulnerable bacteria to this spice was E. faecalis but due to lack of authentic evidences the treatment with this spice was diminished and used as a culinary spice till date to provide flavor without knowing its medicinal values which has given rise to the discovery of synthetic chemical antibiotics to treat these infections. This is an attempt to resurrect the ancient phyto-pharmaceutic techniques for combating the pathogenic bacteria as our time with the synthetic chemical antibiotic drug is draining out which gives rise to the multi-drug bacteria which becomes difficult to be treated. These types of natural resources is an alternate for the toxic synthetic chemicals with zero side effects. Enterococcus faecalis clinical isolate from the different samples showed the best susceptibility with the essential oil extract determined by the Kirby Bauer Disc Diffussion technique with satisfactory MIC and MBC results. The results obtained for the antibacterial properties of Cinnamomum tamala dried leaves essential oil extract recorded were excemplary from the performed standard antibiotic assay which determines that the efficacy of the natural essential oil proved to be an excellent alternative to treat infectious bacterial diseases.

Keywords

Antimicrobial substance, cinnamomum tamala, bay leaf, multi-drug resistant, enterococcus faecalis bacterium.

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