Alginate/k-carrageenan and alginate/gelatin composite hydrogel beads for controlled drug release of curcumin
Biotechnology Laboratory, Department of Chemistry, Sacred Heart College, Kochi 682013, India
Adv. Mater. Lett., 2019, 10 (7), pp 508-514
DOI: 10.5185/amlett.2019.2149
Publication Date (Web): Jan 14, 2019
Copyright © IAAM-VBRI Press
E-mail: jinujacob@shcollege.ac.in
Hydrogel beads based on natural polymers like alginate, κ-Carrageenan, and gelatin represent an efficient scaffold for controlled hydrophobic drug delivery. We report herein the development and characterization different formulations of hydrogel systems based on the above-mentioned polymers having adequate properties as drug delivery matrices. Different combinations of alginate/κ-Carrageenan and alginate/gelatin hydrogel beads were developed and drug release properties were compared using curcumin as a model drug. Alginate/κ-Carrageenan hydrogel beads with 50:50 weight ratio exhibited higher swelling and better drug release percentage than compared to other beads. Antibacterial activity of curcumin released from hydrogel beads against B. cereus was established by disc assay. Encapsulation efficiency and drug release behaviour of different formulations of alginate/κ-Carrageenan and alginate/gelatin indicates that the polymer blends synthesized possess considerable potential in pharmaceutical and medicinal applications. © VBRI Press.
Advanced Materials Research and Innovation Priorities for Accomplishing the Sustainable Development Goals
Contemporary Advances in Humidity Sensing Materials, Methods, and Performances
Roles of the Debye Length and Skin Depth in the Characterization of Space Charge Interactions in Semiconductor Nanoparticles
Antifungal Activity of Iron-gold and Cobalt-gold co-doped ZnO Nanoparticles
Adsorption and Thermodynamic Parameters of Activated Carbon-Diazepam Systems in Simulated Gastric Fluid
Synthesis, Impedance and Current-Voltage Spectroscopic Characterization of Novel Gadolinium Titanate Nano Structures
Removal of Toxic Dyes from Industrial Waste Water using Chitosan Grafted Itaconic Acid Nanocomposites
Structural, Optical and dielectric properties of Sr doped LaVO4
Design, 3D Development and Finite Element Analysis of Cylindrical Mesh Cage Bioimplants from Biometals
Advancements in Materials Technology for Accomplishing Sustainable Development Goals
A Review for Luminescence Property of Materials, Its Detection and Probabilities for Embedding of Luminescence with MEMS Technology
A Review on Low-Cost Adsorbents for Cadmium Pollutant Removal from Industrial Effluents
Study of Applications of Radial Basis Function Network in Forecasting
Simulation of LPG Pressure Vessel under Fire Engulfment
Strength Analysis of Friction Stir Welding (FSW) Joint Under Minimize Rotation Speed of FSW Tool
Formation of Pure In2O3 pallets for OLED Application
Study of Soil Nitrogen Level and Splitting on Nutrient Uptake around the Industries of Chhattisgarh, India