The cover describes the development of nanofibers with encapsulated growth factors has been emerged as a promising approach in neo-tissues applications. The proposed nanofibrous systems provide a novel approach to both simulate the extra-cellular matrix for cell adhesion and also for localized delivery of signaling molecules and growth factors. Growth factors could be loaded into nanofibers using different techniques including physical adsorption, covalent bonding or encapsulation.
Recent advances in nanofibers fabrication and their potential applications in wound healing and regenerative medicine
Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Khartoum Square, 21521, Alexandria, Egypt
Adv. Mater. Lett., 2018, 9 (10), pp 665-676
Publication Date (Web): Jul 27, 2018
Copyright © IAAM-VBRI Press
Nanofibers fabrication is generating considerable interest in terms of their biomedical applications. Recent development in nanofibers fabrication techniques resulted in controlled manipulation of nanofibers characteristics, such as their high surface to volume ratio, high porosity and their ability to encapsulate bioactive molecules. Development of biocompatible, polymer coated nanofibers can also provide an optimal environment for cell adhesion, proliferation and differentiation. This paper presents an overview on different applied techniques for nanofibers fabrication, in addition to the process variables to tailor their physico-chemical characteristics. Furthermore, the current review sheds a new light on the application of nanofibers on treatment of diabetic foot ulcers and artificial skin reconstruction.
Nanofibers, polymeric, wound healing, inorganic composite nanofibers