Efficient siRNA delivery using osmotically active and biodegradable poly(ester amine)  

Jadhav N.1, Min Hye Ahn1, Jaiprakash Sangshetti2, Rohidas B. Arote1, 3*

1Department of Molecular Genetics, School of Dentistry, Seoul National University, Seoul 08826 Republic of Korea

2Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad, MH State, India

3Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, Republic of Korea 

Adv. Mater. Lett., 2018, 9 (8), pp 590-593

DOI: 10.5185/amlett.2018.2026

Publication Date (Web): Jun 14, 2018

E-mail: rohi06@snu.ac.kr

Abstract


Biodegradable and hyperbranched poly(ester amine) (PEA) was prepared by reaction of glycerol dimethacrylate (GDM) with  low molecular weight polyethylenimine (LMW-PEI) by Michael addition reaction. This novel gene carrier showed excellent physicochemical properties and relatively low cytotoxicity compared with PEI 25K. It showed excellent transfection efficiency and siRNA delivery. The higher silencing efficiency of PEAs could be attributed to the synergistic effect arising from hyperosmotic glycerol and proton sponge active PEI residues in the PEA backbone.

Keywords

Poly (ester amine), hyperosmotic effect, proton sponge effect, siRNA delivery.

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