Sensitivity enhanced photo-thermal borders detection in bio-phantoms enriched with gold nanoparticles

Yossef Danan1, 2, Ariel Schwarz1, 2 , Moshe Sinvani1, 2 , Zeev Zalevsky1, 2*

1Faculty of Engineering, Bar-Ilan University, Ramat-Gan, 5290002, Israel

2Institute for Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, 5290002, Israel

Adv. Mater. Lett., 2018, 9 (7), pp 471-475

DOI: 10.5185/amlett.2018.1860

Publication Date (Web): Jun 14, 2018



In the last decade diversity of applications in the fields of diagnostics and treatment for biomedical applications using gold nanoparticles (GNPs) as contrast agent sprang up. The strong optical absorption and scattering properties of the GNPs due to their localized surface plasmon resonance (LSPR) effect enables their use as contrast agents in these applications. The usage of the light-scattering properties of the GNPs in most imaging methods lead to background noise stems from light scattering from the tissue due to the same wavelengths of the illumination source and the GNPs’ scattering. In our previous works we presented a method to improve border detection of bio-phantoms enriched with GNPs leading for real-time complete tumor resection by using a modulated laser illumination, photo thermal imaging camera and the optical absorption of specially targeted GNPs. In this system the thermal camera detects the temperature field of the illuminated bio-phantoms. Although the surrounding area got heated the border location was detected at a precision of at least 0.5 mm through use of a simple post processing technique. In this paper, we present a continuation of our previous research with modified system of time sequence labelling (TSL) processing for improved border detection capable of operating and detecting borders at much lower signal to noise levels.


Photo thermal imaging, gold nanoparticles, localized surface plasmon resonance, image processing.

Current Issue
The Journey of a Decade to Advancing Materials
Are the Electrospun Polymers Polymeric Fibers?
Mechanical and Thermal Properties of Composite Material and Insulation for a Single Walled Tank for Cryogenic Liquids
Prediction of Long-Term Behavior for Dynamically Loaded TPU
Investigation of Doped Titanium Dioxide in Anatase Phase. Study ab initio using Density Functional Theory
Comparison between Single Al2O3 or HfO2 Single Dielectric Layers and their Nanolaminated Systems
Preparation of Stable and Optimized Antibody-gold Nanoparticle Conjugates for Point of Care Test Immunoassays
Resonance-Based Temperature Sensors using a Wafer Level Vacuum Packaged SOI MEMS Process
Integrated System Based on the Hall Sensors Incorporating Compensation of the Distortions
The Efficacy of Cinnamomum Tamala as a Potential Antimicrobial Substance against the Multi-Drug Resistant Enterococcus Faecalis from Clinical Isolates
The Effect of Complexing Reagent on Structural, Electrical and Optical Properties of CuS Thin Film
Laser Cladding of Fluorapatite Nanopowders on Ti6Al4V
Preparation and Evaluation of Sulfonate Polyethylene Glycol Borate Ester as a Modifier of Functional Properties of Complex Petroleum Lithium Grease

Upcoming Congress

Knowledge Experience at Sea TM