Composite BME-AuNPs: Chemopreventive effect on skin carcinoma and inhibition on leukemia blood cance
1Departmentof pharmacology, K. L. E. S College of Pharmacy, Hubli, Karnataka, 580 031, India
2Deparment of Animal Biology, School of life Sciences, University of Hyderabad, 500 046, India
3Deparment of Biochemistry, Acharya Nagarjuna University, Andhra Pradesh, 522 510, India
4School of Engineering Sciences and Technology, University of Hyderabad, Hyderabad, 500 046, India
Adv. Mater. Lett., 2017, 8 (11), pp 1057-1064
Publication Date (Web): Aug 05, 2017
Copyright © IAAM-VBRI Press
Herein, the chemopreventive effect of oral and topical administration of composite of alcoholic plant extracts of Butea monosperma (Lam.) Taub. (BME) leaves and gold nanoparticles (Au NPs) have been investigated. The tumor growth has been initiated by the 7, 12-dimethyl benz (a) anthracene (DMBA) and skin tumorigenesis in male Swiss albino mice were promoted by the 12-O-tetradecanoylphorbol-13-acetate (TPA). However, malignant feature of the skin tumors were treated with composite of (BME-Au NPs) to reduce the tumor incidence, tumor burden, tumor yield, cumulative number of tumors, tumor size, mass, and volume, respectively. Furthermore, studies were extended to treat CML (chronic myeloid leukemia) K562 (blood cancer) cells with the combination of DMBA/TPA-(BME-Au NPs) and it show greater (~80%) cellular inhibition on cancer cells. Compare to BME alone the composite of (BME-Au NPs) shows significant effect on skin carcinoma and as well on cancer cells.
Chemopreventive, plant extract, composite, cell inhibition, skin carcinoma.