1Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Panepistimiopolis, Zografou, 15771, Greece
2Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, Athens, 48 Vassileos Constantinou Aveneu, 11635, Greece
3Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Warszawa, 00901, Poland
Adv. Mater. Lett., 2017, 8 (4), pp 428-434
DOI: 10.5185/amlett.2017.1414
Publication Date (Web): Mar 14, 2017
Copyright © IAAM-VBRI Press
E-mail: natpippa@pharm.uoa.gr
The aim of this investigation was to study the alterations of the physicochemical characteristics of L-α-phosphatidylcholine, hydrogenated (Soy) (HSPC) and dipalmitoyl phosphatidyl choline (DPPC) liposomes, caused by the incorporation of a poly (oligoethylene glycol acrylate)-b-poly(lauryl acrylate) (POEGA-PLA) block copolymer at different molar ratios. We used Dynamic and Electrophoretic Light Scattering to determine the size and the ζ-potential; imaging techniques for investigate the structure and Static Light Scattering for quantifying the fractal morphology of the prepared nanosystems in situ. The size of mixed nanostructures became smaller with the incorporation of the block copolymer into the lipid membrane. The size of the prepared nanosystems ranged between 50-80nm. The fractal dimension (df) decreased significantly with the incorporation of block copolymer into liposomal bilayers. The morphology of DPPC:POEGA-PLA mixed nanostructures (with df equal to 1.8) is open (more loose). On the other hand, the morphology of HSPC: POEGA-PLA (with df equal to 2.1) is more compact and dense. The molar ratio of the POEGA-PLA did not alter the morphology of the mixed nanostructures, expect from HSPC:POEGA-PLA system. Finally, we studied the drug loading properties of the mixed nanostructures in order to examine their properties as advanced Drug Delivery nanosystems.
Advanced Materials Congress Celebrating 10th Years of Establishment
Secure Management of Networked Batteries for Building Integrated Photovoltaics (BIPV) Systems
The Cause of 100-year Low Carbonated Concrete of the Bridge
Organic Montmorillonite Intercalated Nano-composites Prevent Post-Surgical Associated Infections
Morphology/tensile Performance Relationship for LLDPE/PP Double Gated Injected Blends
Preparation and Characterization of Nickel Ferrite Nanoparticles via Sol-gel Method
Nitrogen-doped Diamond Nanowire Gas Sensor for the Detection of Methane
Manufacture of Functional Open-cell Al Foams with Recycled Al Scraps using NaCl Ball Space Holder
Vilsmeier-Haack Transformations under Non Classical Conditions
New Application of Highly Vesicular Basalt from Jabel Isbil Volcano (Dhamar-Rada'a Volcanic Field), Yemen
An Assessment of Tribological Characteristics under different Operating Condition
Functional Bi Coatings as A Perspective Material for Radiation Shields Production against Electron Radiation
Effects of Silica Modified NiFe2O4 on the Dielectric and Electrical Properties of NiFe2O4 filled Poly (methyl methacrylate) Composites
_1572929082.jpg)
Copyright ©2010-2020 VBRI Press
Full Article