Fabrication of Nanoparticle Embedded Polymeric Microbeads as an Efficient Drug Delivery System

Geetanjali, Bhavani P. Nenavathu*

Department of Applied Sciences and Humanities, Indira Gandhi Delhi Technical University for Women, Delhi 110006, India

DOI: 10.5185/amlett.2019.0003

Publication Date (Web): May 22, 2019

Corresponding author: E-mail: bhavaniprasadnaik@igdtuw.ac.in; Tel: (+91) 11-23900275


An efficient theragnostic which offers diagnosis and therapy of cancer is developed using a polymer based nanocarrier embedded with fluorescent quantum dots by the ionotropic gelation method. The FTIR spectra provide direct evidence of formation of polymer based nanocarrier comprising chitosan-alginate micro beads (CS-ALG beads). Notably, the SEM images showed highly porous structure of polymeric beads without Ag NPs and CdS QDs. The morphology of CS-ALG beads loaded with Ag NPs and CdS QDs showed smooth surface, glossy, homogenous shape under scanning electron microscopy and it could be due to high loading of fluorescent and silver NPs. The EDX analysis of as synthesised nanoparticle embedded polymeric beads showed X-ray peaks of Cd, S corresponds to CdS NPs. And the X- Ray peaks of C, O corresponds to the polymer beads.  Characterization of nanocarrier for the presence of polymers has been confirmed by studies carried out using thermogravimetric analysis (TGA) showed complete degradation of Chitosan at about 450 °C while calcium alginate exhibits three-step decomposition. Further, the swelling studies of dried CS-ALG beads were carried out at room temperature and about 97% of swelling is being observed at pH 5 in 45 min. and 44% swelling is observed at pH 2. © VBRI Press.


Chitosan-calcium alginate microbeads, silver nanoparticles, ionotropic gelation, drug delivery system, quantum dots.

Current Issue

Smart Healthcare pulls up Clouds for Virtual Medicine

Selecting the correct electromagnetic inspection technology 

Influence of railway-track grinding on the track material condition and tribological behaviour

Micromechanical Fatigue Modelling of the Size Effect in Micro-Scale 316L Stainless Steel Specimens

Functionalization of Graphene and Reduced Graphene Oxide in Different Matrices

Effect of parasitic polytypes on ballistic electron transport in chemical vapor deposition grown 6H-SiC epitaxial layers

Photomemristive heterostructures based on two-dimensional crystals

Architecture - behaviour - properties relationship in Star-shaped MPA-PMMA and MPA-PS hyper-branched copolymers

Graphene and doped graphene: A comparative DFT study

Ag2CO3 / Magnetic reduced graphene oxide nanocomposite as advanced visible light photocatalytic hybrid materials for efficient degradation of azo dye

Optimization of acid hydrolysis process for the preparation cellulose nanofibrils

Alginate/k-carrageenan and alginate/gelatin composite hydrogel beads for controlled drug release of curcumin

Study of microstructure and mechanical properties of friction stir welded ferrite-martensite DP700 steel

Previous issues

9th Anniversary of Advanced Materials Letters: Progress and Opportunities

Coating - A potent method to enhance electrochemical performance of Li(NixMnyCoz)O2 cathodes for Li-ion batteries

Analysis of machined electron beam treated Ti6Al4V-ELI implant surfaces

Bottom-up design of hydrogels through click-chemistry modification of magnetic nanoparticles

Visualization of mechanical loads with semiconductor nanocrystals 

Room temperature growth of ultra porous hot-wire deposited tantalum pentoxide

Substrate integrated circular cavity resonator filled with nano-fibrillated cellulose for humidity detection

Oxygen vacancy filament-based resistive switching in Hf0.5Zr0.5O2 thin films for non-volatile memory

Innovative silicon compatible materials for light emitting devices  

Graphene micromesh for transparent conductive films application 

Applications of nano-scale Cirrus DopantTM to improve existing coatings

Chitin nanofibrils in renewable materials for packaging and personal care applications

Synthesis of AgNPs embedded double network nanocomposite hydrogels having high swelling and anti-bacterial characteristics

Upcoming Congress

Knowledge Experience at Sea TM